ArticleAnnals of the rheumatic diseases2009
Is the blood B-cell subset profile diagnostic for Sjogren syndrome?
Article in Annals of the rheumatic diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 85 citations in OpenAlex.
- Distribution of multi-level B cell subsets in thymoma and thymoma-associated myasthenia gravis.Scientific reports · 2024Article
- Added value of lymphocyte subpopulations in the classification of Sjögren's syndrome.Scientific reports · 2023Article
- Alterations in B- and circulating T-follicular helper cell subsets in immune thrombotic thrombocytopenic purpura.Blood advances · 2022Article
- Immune Monitoring upon Treatment with Biologics in Sjögren's Syndrome: The What, Where, When, and How.Biomolecules · 2021Review
- Elevated expression of BAFF receptor, BR3, on monocytes correlates with B cell activation and clinical features of patients with primary Sjögren's syndrome.Arthritis research & therapy · 2020Article
- Imbalance in B cell and T Follicular Helper Cell Subsets in Pulmonary Sarcoidosis.Scientific reports · 2020Article
- Tissue Infiltrating LTi-Like Group 3 Innate Lymphoid Cells and T Follicular Helper Cells in Graves' and Hashimoto's Thyroiditis.Frontiers in immunology · 2020Article
- B cell dysregulation in primary Sjögren's syndrome: A review.The Japanese dental science review · 2019Review
- Peripheral-blood b-cell subset disturbances in inflammatory joint diseases induced by Tropheryma whipplei.PloS one · 2019Article
- Diminished CXCR5 expression in peripheral blood of patients with Sjögren's syndrome may relate to both genotype and salivary gland homing.Clinical and experimental immunology · 2018Article
- Association between memory B-cells and clinical and immunological features of primary Sjögren's syndrome and Sicca patients.Rheumatology international · 2018Article
- Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity.Clinical reviews in allergy & immunology · 2017Review
- Could Lymphocyte Profiling be Useful to Diagnose Systemic Autoimmune Diseases?Clinical reviews in allergy & immunology · 2017Review
- Lymphocyte Disturbances in Primary Antiphospholipid Syndrome and Application to Venous Thromboembolism Follow-Up.Clinical reviews in allergy & immunology · 2017Review
- Update on Pathogenesis of Sjogren's Syndrome.Current rheumatology reviews · 2017Review
- The Differential Diagnosis of Dry Eyes, Dry Mouth, and Parotidomegaly: A Comprehensive Review.Clinical reviews in allergy & immunology · 2015Review
- Primary Sjögren's syndrome is characterized by distinct phenotypic and transcriptional profiles of IgD+ unswitched memory B cells.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- Diagnostic accuracy of blood B-cell subset profiling and autoimmunity markers in Sjögren's syndrome.Arthritis research & therapy · 2014Article
- High-dose methylprednisolone pulse therapy upregulated FcγRIIb expression on B cells in primary Sjögren's syndrome patients with thrombocytopenia.Clinical rheumatology · 2013Article
- CXCL13 is elevated in Sjögren's syndrome in mice and humans and is implicated in disease pathogenesis.Journal of leukocyte biology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the relevance of the blood B-cell subset profile for the diagnosis of Sjögren syndrome.
methodsThe distribution of mature blood B cells from Bm1 through Bm5 was determined in 161 patients, of whom 25 fulfilled the American-European Consensus Group criteria for primary SS (pSS), and 136 served as disease controls.
resultsThe percentage of Bm2 and Bm2' cells was increased in the patients with pSS compared with 54 patients with rheumatoid arthritis (RA) and 18 with systemic lupus erythematosus (SLE) (p<0.001 for the two comparisons). In contrast, those of early Bm5 (eBm5) and Bm5 were decreased in patients with pSS, compared with patients with RA and with SLE (p<0.001 for the two comparisons). The receiver operating characteristic curves allowed for an optimising cut-off value of Bm2+Bm2' cells at 71.1% for 88.0% sensitivity and 83.1% specificity, that of eBm5+Bm5 cells at < or =13.5% for 84.0% sensitivity and 83.1% specificity, and, consequently, that of Bm2+Bm2'/eBm5+Bm5 at > or =5 for 88.0% sensitivity and 84.6% specificity.
conclusionGiven its presentation as a signature for pSS, relative to RA and SLE, such a distribution of B-cell subsets might provide a useful diagnostic tool.
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