ArticleBMC evolutionary biology2008
Metabolic innovations towards the human lineage.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Impact of constitutional copy number variants on biological pathway evolution.BMC evolutionary biology · 2013Article
- Evolution of domain architectures and catalytic functions of enzymes in metabolic systems.Genome biology and evolution · 2012Article
- Origins of specificity and promiscuity in metabolic networks.The Journal of biological chemistry · 2011Article
- A systems biology approach for the investigation of the heparin/heparan sulfate interactome.The Journal of biological chemistry · 2011Article
- Protein coalitions in a core mammalian biochemical network linked by rapidly evolving proteins.BMC evolutionary biology · 2011Article
- Cholesterol, the central lipid of mammalian cells.Current opinion in cell biology · 2010Review
- Evolutionary constraints permeate large metabolic networks.BMC evolutionary biology · 2009Article
- The conservation and evolutionary modularity of metabolism.Genome biology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe describe a function-driven approach to the analysis of metabolism which takes into account the phylogenetic origin of biochemical reactions to reveal subtle lineage-specific metabolic innovations, undetectable by more traditional methods based on sequence comparison. The origins of reactions and thus entire pathways are inferred using a simple taxonomic classification scheme that describes the evolutionary course of events towards the lineage of interest. We investigate the evolutionary history of the human metabolic network extracted from a metabolic database, construct a network of interconnected pathways and classify this network according to the taxonomic categories representing eukaryotes, metazoa and vertebrates.
resultsIt is demonstrated that lineage-specific innovations correspond to reactions and pathways associated with key phenotypic changes during evolution, such as the emergence of cellular organelles in eukaryotes, cell adhesion cascades in metazoa and the biosynthesis of complex cell-specific biomolecules in vertebrates.
conclusionThis phylogenetic view of metabolic networks puts gene innovations within an evolutionary context, demonstrating how the emergence of a phenotype in a lineage provides a platform for the development of specialized traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.