ReviewExpert opinion on therapeutic targets2008
Targeting angiogenin in therapy of amyotropic lateral sclerosis.
Review in Expert opinion on therapeutic targets, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- The Inflammatory Puzzle: Piecing together the Links between Neuroinflammation and Amyotrophic Lateral Sclerosis.Aging and disease · 2024Review
- Astrocyte-Neuron Interactions Contributing to Amyotrophic Lateral Sclerosis Progression.Advances in neurobiology · 2024Review
- Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines.Computational and structural biotechnology journal · 2023Article
- Protective Effects of Recombinant Human Angiogenin in Keratinocytes: New Insights on Oxidative Stress Response Mediated by RNases.International journal of molecular sciences · 2022Article
- The Therapeutic Potential of tRNA-derived Small RNAs in Neurodegenerative Disorders.Aging and disease · 2022Review
- Peptides Derived from Angiogenin Regulate Cellular Copper Uptake.International journal of molecular sciences · 2021Article
- Loss of angiogenin function is related to earlier ALS onset and a paradoxical increase in ALS duration.Scientific reports · 2020Article
- Functional roles of the human ribonuclease A superfamily in RNA metabolism and membrane receptor biology.Molecular aspects of medicine · 2019Review
- A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases.Journal of biomedical science · 2018Review
- Expression and Distribution of Arylsulfatase B are Closely Associated with Neuron Death in SOD1 G93A Transgenic Mice.Molecular neurobiology · 2018Article
- The Many Virtues of tRNA-derived Stress-induced RNAs (tiRNAs): Discovering Novel Mechanisms of Stress Response and Effect on Human Health.The Journal of biological chemistry · 2015Review
- Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosis.PloS one · 2014Article
- Lack of unique neuropathology in amyotrophic lateral sclerosis associated with p.K54E angiogenin (ANG) mutation.Neuropathology and applied neurobiology · 2013Article
- NeuroDNet - an open source platform for constructing and analyzing neurodegenerative disease networks.BMC neuroscience · 2013Article
- ANGDelMut - a web-based tool for predicting and analyzing functional loss mechanisms of amyotrophic lateral sclerosis-associated angiogenin mutations.F1000Research · 2013Article
- Prediction of functional loss of human angiogenin mutants associated with ALS by molecular dynamics simulations.Scientific reports · 2013Article
- Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress.The Journal of biological chemistry · 2012Article
- Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.Nature communications · 2012Article
- New insights into the role of angiogenin in actin polymerization.International review of cell and molecular biology · 2012Review
- Angiogenin-mediated rRNA transcription in cancer and neurodegeneration.International journal of biochemistry and molecular biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMissense heterozygous mutations in the coding region of angiogenin (ANG) gene, encoding a 14 kDa angiogenic RNase, were recently found in patients of amyotropic lateral sclerosis (ALS). Functional analyses have shown that these are loss-of-function mutations, implying that angiogenin deficiency is associated with ALS pathogenesis and that increasing ANG expression or angiogenin activity could be a novel approach for ALS therapy.
objectiveReview the evidence showing the involvement of angiogenin in motor neuron physiology and function, and provide a rationale for targeting angiogenin in ALS therapy.
methodsReview the current understanding of the mechanism of angiogenin action in connection with ALS genetics, pathogenesis and therapy.
conclusionANG is the first gene whose loss-of-function mutations are associated with ALS pathogenesis. Therapeutic modulation of angiogenin level and activity in the spinal cord, either by systemic delivery of angiogenin protein or through retrograde transport of ANG-encoding viral particles, may be beneficial for ALS patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.