ReviewHuman genetics2008
Osteoporosis: an evolutionary perspective.
Review in Human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Weaker bones and white skin as adaptions to improve anthropological "fitness" for northern environments.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Review
- 'Evolutionary medicine' perspectives on Alzheimer's Disease: Review and new directions.Ageing research reviews · 2018Review
- High osteoporosis risk among East Africans linked to lactase persistence genotype.BoneKEy reports · 2016Article
- Diametrical diseases reflect evolutionary-genetic tradeoffs: Evidence from psychiatry, neurology, rheumatology, oncology and immunology.Evolution, medicine, and public health · 2015Review
- Gracility of the modern Homo sapiens skeleton is the result of decreased biomechanical loading.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Osteoporosis.Evolution, medicine, and public health · 2015Article
- Impact of the environment on the skeleton: is it modulated by genetic factors?Current osteoporosis reports · 2013Review
- Androgen receptor polyglutamine repeat number: models of selection and disease susceptibility.Evolutionary applications · 2013Article
- Nmp4/CIZ closes the parathyroid hormone anabolic window.Critical reviews in eukaryotic gene expression · 2012Review
- How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging.Age (Dordrecht, Netherlands) · 2011Review
- Human evolution and osteoporosis-related spinal fractures.PloS one · 2011Article
- Evaluation of mental index, mandibular cortical index and panoramic mandibular index on dental panoramic radiographs in the elderly.European journal of dentistry · 2011Article
- Genetics of osteoporosis: accelerating pace in gene identification and validation.Human genetics · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Increased life expectancy has led to an overall aging of the population and greater numbers of elderly people. Therefore, the number of people with osteoporosis has increased substantially, accompanied with an epidemic of hip fractures. Osteoporosis is an age-related systemic condition that naturally occurs, among mammals, only in humans. Osteoporosis is known to be highly heritable. However, assuming a genetic determinant for this post-reproductive disease to be transmitted from one generation to the next is counter-intuitive, based on the principles of human evolution, I will attempt to provide an explanation of the phenomenon from the point of view of evolution, selection, and changed environment in humans, which contributed to human longevity, while on other hand, contribute to diseases of civilization, including osteoporosis. There is a need to delve into evolution of human species in search for adaptive patterns to a specific environment that humans are operating in the last couple of millennia, to clarify whether "good" and "bad" genes exist, and how to find and correct them. The answer to the above questions will help us to identify causes of the current epidemic of osteoporosis and to pin-point a tailored treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.