ArticleJournal of neural transmission (Vienna, Austria : 1996)2008
Promoter polymorphisms modulating HSPA5 expression may increase susceptibility to Taiwanese Alzheimer's disease.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 33 citations in OpenAlex.
- Exploring Brain Imaging and Genetic Risk Factors in Different Progression States of Alzheimer's Disease Through OSnetNMF-Based Methods.Journal of molecular neuroscience : MN · 2025Article
- Chaperone-Dependent Mechanisms as a Pharmacological Target for Neuroprotection.International journal of molecular sciences · 2023Review
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- Genetic association of promoter in GRP78 gene with nasopharyngeal carcinoma in a Chinese population.International journal of clinical oncology · 2019Article
- Association of GRP78 promoter polymorphisms and serum GRP78 level with risk of asthenozoospermia.Journal of assisted reproduction and genetics · 2018Article
- Proteomic differences in brain vessels of Alzheimer's disease mice: Normalization by PPARγ agonist pioglitazone.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Structural and functional analysis of novel human cytochrome C targets in apoptosis.Molecular & cellular proteomics : MCP · 2014Article
- Association between promoter polymorphisms of the GRP78 gene and risk of type 2 diabetes in a Chinese Han population.DNA and cell biology · 2013Article
- Polymorphisms of glucose-regulated protein 78 and risk of colorectal cancer: a case-control study in southwest China.PloS one · 2013Article
- Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives.The Journal of biological chemistry · 2012Article
- Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics.International journal of Alzheimer's disease · 2012Article
- GRP78 promoter polymorphism rs391957 as potential predictor for clinical outcome in gastric and colorectal cancer patients.Annals of oncology : official journal of the European Society for Medical Oncology · 2011Article
- Genomics and pharmacogenomics of dementia.CNS neuroscience & therapeutics · 2011Review
- MicroRNA-related cofilin abnormality in Alzheimer's disease.PloS one · 2010Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endoplasmic reticulum (ER) chaperone heat shock 70 kDa protein 5 (HSPA5/GRP78) is known to be involved in the metabolism of amyloid precursor protein and neuronal death in Alzheimer's disease (AD) could arise from dysfunction of the ER. Through a case-control study and an expression assay, we investigated the association of HSPA5 -415 G/A (rs391957), -370 C/T (rs17840761) and -180 del/G (rs3216733) polymorphisms with Taiwanese AD. The overall genotype and allele frequency distribution at the completely linked -415 G/A and -180 del/G sites showed significant difference between AD cases and controls (P = 0.020 and 0.009, respectively). A decrease in risk of developing AD was demonstrated for -415 AA/-180 GG genotype [OR = 0.38, 95% confidence interval (CI) = 0.18-0.75, P = 0.007] and -415 A/-180 G allele (OR = 0.69, 95% CI = 0.51-0.91, P = 0.009). The HSPA5 transcriptional activity of the -415 A/-180 G allele was significantly lower than that of the -415 G/-180 del alleles, whereas induction of HSPA5 expression after ER stress was markedly increased in the cells with the -415 A/-180 G allele. Therefore, our preliminary results may suggest a protective role of the HSPA5 -415 A/-180 G allele in Taiwanese AD susceptibility.
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