ArticleEuropean journal of human genetics : EJHG2009
Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study).
Article in European journal of human genetics : EJHG, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia.Scientific reports · 2013Pooled it
- ACVR2A facilitates trophoblast cell invasion through TCF7/c-JUN pathway in pre-eclampsia progression.eLife · 2025Article
- The First Evidence for the Role of ACVR2A Gene Fetal Genotype in Preeclampsia Susceptibility.Molecular genetics & genomic medicine · 2025Article
- Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population.World journal of gastrointestinal oncology · 2025Article
- TGFβ signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy.Human reproduction update · 2024Review
- Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human.Science translational medicine · 2024Article
- Article
- Machine-learning predictive model of pregnancy-induced hypertension in the first trimester.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics.Ageing research reviews · 2022Review
- Genetic variants in anti-Müllerian hormone-related genes and breast cancer risk: results from the AMBER consortium.Breast cancer research and treatment · 2021Article
- Non-additive effects of ACVR2A in preeclampsia in a Philippine population.BMC pregnancy and childbirth · 2019Article
- Analysis of the Epigenome in Multiplex Pre-eclampsia Families IdentifiesFrontiers in genetics · 2019Article
- Genetic predisposition to preeclampsia is conferred by fetal DNA variants near FLT1, a gene involved in the regulation of angiogenesis.American journal of obstetrics and gynecology · 2018Review
- The TGF-β Family in the Reproductive Tract.Cold Spring Harbor perspectives in biology · 2017Review
- Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Genetic aspects of preeclampsia and the HELLP syndrome.Journal of pregnancy · 2014Review
- Network of microRNAs-mRNAs interactions in pancreatic cancer.BioMed research international · 2014Article
- (Epi)genetics of pregnancy-associated diseases.Frontiers in genetics · 2013Review
- Genetic dissection of the pre-eclampsia susceptibility locus on chromosome 2q22 reveals shared novel risk factors for cardiovascular disease.Molecular human reproduction · 2013Article
- Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an American Indian population.PloS one · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Genome-wide scans in Icelandic, Australian/New Zealand and Finnish pedigrees have provided evidence for maternal susceptibility loci for pre-eclampsia on chromosome 2, although at different positions (Iceland: 2p13 and 2q23, Australia/New Zealand: 2p11-12 and 2q22, Finland: 2p25). In this project, a large population-based (n=65 000) nested case-control study was performed in Norway to further explore the association between positional candidate genes on chromosome 2q and pre-eclampsia, using single-nucleotide polymorphisms (SNPs). DNA samples from 1139 cases (women with one or more pre-eclamptic pregnancies) and 2269 controls (women with normal pregnancies) were genotyped using the Applied Biosystems SNPlex high-throughput genotyping assay. In total, 71 SNPs within positional candidate genes at 2q22-23 locus on chromosome 2 were genotyped in each individual. Genotype data were statistically analysed with the sequential oligogenic linkage analysis routines (SOLAR) computer package. Nominal evidence of association was found for six SNPs (rs1014064, rs17742134, rs1424941, rs2161983, rs3768687 and rs3764955) within the activin receptor type 2 gene (ACVR2A) (all P-values <0.05). The non-independence of statistical tests due to linkage disequilibrium between SNPs at a false discovery rate of 5% identifies our four best SNPs (rs1424941, rs1014064, rs2161983 and rs3768687) to remain statistically significant. The fact that populations with different ancestors (Iceland/Norway-Australia/New Zealand) demonstrate a common maternal pre-eclampsia susceptibility locus on chromosome 2q22-23, may suggest a general role of this locus, and possibly the ACVR2A gene, in pre-eclampsia pathogenesis.
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