SynthesisEuropean journal of human genetics : EJHG2009
Meta-analysis of genome-wide linkage studies across autoimmune diseases.
Synthesis in European journal of human genetics : EJHG, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Risk of Cancer in Patients with Rheumatoid Arthritis Compared with the General Population: A Nationwide Cohort Study in Lithuania.Medicina (Kaunas, Lithuania) · 2026Article
- Crohn's Disease-Associated and Cryptoglandular Fistulas: Differences and Similarities.Journal of clinical medicine · 2023Review
- Editorial: Targeting antigen processing and presentation in autoimmune and autoinflammatory disorders.Frontiers in immunology · 2022Article
- Polymorphisms in theCanine medicine and genetics · 2020Article
- Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing.The pharmacogenomics journal · 2019Article
- History of autoimmune disease is associated with impaired survival in multiple myeloma and monoclonal gammopathy of undetermined significance: a population-based study.Annals of hematology · 2017Article
- Familial associations of lymphoma and myeloma with autoimmune diseases.Blood cancer journal · 2017Article
- Origin of B-Cell Neoplasms in Autoimmune Disease.PloS one · 2016Article
- The effect of genetic bottlenecks and inbreeding on the incidence of two major autoimmune diseases in standard poodles, sebaceous adenitis and Addison's disease.Canine genetics and epidemiology · 2015Article
- Recursive organizer (ROR): an analytic framework for sequence-based association analysis.Human genetics · 2013Article
- Progress in multiple sclerosis genetics.Current genomics · 2012Article
- The multiple autoimmune syndromes. A clue for the autoimmune tautology.Clinical reviews in allergy & immunology · 2012Article
- Effect of autoimmune diseases on incidence and survival in subsequent multiple myeloma.Journal of hematology & oncology · 2012Article
- The immunogenetic architecture of autoimmune disease.Cold Spring Harbor perspectives in biology · 2012Review
- Familial association between type 1 diabetes and other autoimmune and related diseases.Diabetologia · 2009Article
- Use and Safety of Viscum album L Applications in Cancer Patients With Preexisting Autoimmune Diseases: Findings From the Network Oncology Study.Integrative cancer therapiesArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Autoimmune diseases are chronic disorders initiated by a loss of immunologic tolerance to self-antigens. They cluster within families, and patients may be diagnosed with more than one disease, suggesting pleiotropic genes are involved in the aetiology of different diseases. To identify potential loci, which confer susceptibility to autoimmunity independent of disease phenotype, we pooled results from genome-wide linkage studies, using the genome scan meta-analysis method (GSMA). The meta-analysis included 42 independent studies for 11 autoimmune diseases, using 7350 families with 18 291 affected individuals. In addition to the HLA region, which showed highly significant genome-wide evidence for linkage, we obtained suggestive evidence for linkage on chromosome 16, with peak evidence at 10.0-19.8 Mb. This region may harbour a pleiotropic gene (or genes) conferring risk for several diseases, although no such gene has been identified through association studies. We did not identify evidence for linkage at several genes known to confer increased risk to different autoimmune diseases (PTPN22, CTLA4), even in subgroups of diseases consistently found to be associated with these genes. The relative risks conferred by variants in these genes are modest (<1.5 in most cases), and even a large study like this meta-analysis lacks power to detect linkage. This study illustrates the concept that linkage and association studies have power to identify very different types of disease-predisposing variants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.