ArticleBritish journal of cancer2008
Deregulation of MUC4 in gastric adenocarcinoma: potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer.
Article in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Single-cell Profiling Uncovers aCancer research communications · 2023Article
- Mucins as contrast agent targets for fluorescence-guided surgery of pancreatic cancer.Cancer letters · 2023Review
- Multi-omics analysis of the Indian ovarian cancer cohort revealed histotype-specific mutation and gene expression patterns.Frontiers in genetics · 2023Article
- Whole-Exome Sequencing Among Chinese Patients With Hereditary Diffuse Gastric Cancer.JAMA network open · 2022Article
- Family-based exome sequencing combined with linkage analyses identifies rare susceptibility variants of MUC4 for gastric cancer.PloS one · 2020Article
- Genome-Wide Characterization of RNA Editing Sites in Primary Gastric Adenocarcinoma through RNA-seq Data Analysis.International journal of genomics · 2020Article
- Helicobacter-induced gastric inflammation alters the properties of gastric tissue stem/progenitor cells.BMC gastroenterology · 2017Article
- Mucin-Type O-Glycosylation in Gastric Carcinogenesis.Biomolecules · 2016Review
- Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer.Oncogene · 2016Article
- Genetically engineered mucin mouse models for inflammation and cancer.Cancer metastasis reviews · 2015Review
- Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers.World journal of gastroenterology · 2014Article
- Altered Mucins (MUC) trafficking in benign and malignant conditions.Oncotarget · 2014Review
- The co-expression of functional gastric proteins in dynamic gastric diseases and its clinical significance.BMC clinical pathology · 2013Article
- Establishment and characterization of novel gastric signet-ring cell and non signet-ring cell poorly differentiated adenocarcinoma cell lines with low and high malignant potential.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2013Article
- Prognostic significance of membrane-associated mucins 1 and 4 in gastric adenocarcinoma.Experimental and therapeutic medicine · 2012Article
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- Helicobacter felis--associated gastric disease in microbiota-restricted mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin MUC4 in pancreatic cancer.PloS one · 2011Article
- Aberrant upregulation of MUC4 mucin expression in cutaneous condyloma acuminatum and squamous cell carcinoma suggests a potential role in the diagnosis and therapy of skin diseases.Journal of clinical pathology · 2010Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
MUC4 is a large, heavily glycosylated transmembrane mucin, that is implicated in the pathogenesis of various types of cancers. To date, no extensive study has been done to check the expression and functional significance of MUC4 in different types of gastric adenocarcinomas. Here, we report the expression profile of MUC4 in gastric adenocarcinomas and its function in poorly differentiated gastric non-signet ring cell carcinoma (non-SRCC) type cells. Immunohistochemical analysis using tissue microarray (TMA) showed a significant difference in MUC4 expression between normal adjacent (n = 45) and gastric adenocarcinoma (n = 83; P < 0.001). MUC4 expression was not associated with tumour type, stage or with the degree of differentiation. To gain further insight into the significance of MUC4 expression in gastric non-SRCC cells, MUC4 was ectopically expressed in AGS, a poorly differentiated gastric non-signet ring cell line. The MUC4 overexpressing cells (AGS-MUC4) showed a significant increase (P < 0.005) in cell motility and a decrease in cellular aggregation as compared with the vector-transfected cells. Furthermore, in vivo tumorigenicity analysis revealed that animals transplanted with the MUC4 overexpressing cells (AGS-MUC4) had a greater incidence of tumours (83%) in comparison to empty vector control (17%). In addition, the expression of MUC4 resulted in enhanced expression of total cellular ErbB2 and phosphorylated ErbB2. In conclusion, our results showed that MUC4 is overexpressed in gastric adenocarcinoma tissues, and that it has a role in promoting aggressive properties in poorly differentiated gastric non-SRCC cells through the activation of the ErbB2 oncoprotein.
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