ArticlePhysiological genomics2008
Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling.
Article in Physiological genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Perioperative Considerations of Novel Antidiabetic Agents in Heart Failure Patients Undergoing Cardiac Surgery.Life (Basel, Switzerland) · 2025Review
- Tachycardia-induced metabolic rewiring as a driver of contractile dysfunction.Nature biomedical engineering · 2024Article
- Implications for neutrophils in cardiac arrhythmias.American journal of physiology. Heart and circulatory physiology · 2024Review
- Ion Channel Impairment and Myofilament CaCells · 2021Review
- Sensitivity Analysis of Ion Channel Conductance on Myocardial Electromechanical Delay: Computational Study.Frontiers in physiology · 2021Article
- Full-Length Transcriptome Sequencing: An Insight Into the Dog Model of Heart Failure.Frontiers in cardiovascular medicine · 2021Article
- COVID-19: Electrophysiological mechanisms underlying sudden cardiac death during exercise with facemasks.Medical hypotheses · 2020Article
- A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure.NPJ systems biology and applications · 2018Article
- Mitochondrial cardiomyopathies feature increased uptake and diminished efflux of mitochondrial calcium.Journal of molecular and cellular cardiology · 2017Article
- A comprehensive review of the bioenergetics of fatty acid and glucose metabolism in the healthy and failing heart in nondiabetic condition.Heart failure reviews · 2017Review
- The Affordable Care Act's Hospital Readmissions Reduction Program: Has the Biology Had Time to Catch Up With the Regulation?JACC. Basic to translational science · 2016Article
- Article
- Dynamic gene expression patterns in animal models of early and late heart failure reveal biphasic-bidirectional transcriptional activation of signaling pathways.Physiological genomics · 2014Article
- Pathological ventricular remodeling: therapies: part 2 of 2.Circulation · 2013Article
- Transcriptome, proteome, and metabolome in dyssynchronous heart failure and CRT.Journal of cardiovascular translational research · 2012Review
- Cellular electrophysiological abnormalities in dyssynchronous hearts and during CRT.Journal of cardiovascular translational research · 2012Review
- Metabolic stress, reactive oxygen species, and arrhythmia.Journal of molecular and cellular cardiology · 2012Review
- The molecular fingerprint of cardiac dyssynchrony and cardiac resynchronization therapy.Heart failure reviews · 2011Review
- Deciphering Arrhythmia Mechanisms - Tools of the Trade.Cardiac electrophysiology clinics · 2011Article
- Computational models reduce complexity and accelerate insight into cardiac signaling networks.Circulation research · 2011Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Heart failure (HF) is the leading cause of morbidity and mortality in the industrialized world. While the transcriptomic changes in end-stage failing myocardium have received much attention, no information is available on the gene expression patterns associated with the development of HF in large mammals. Therefore, we used a well-controlled canine model of tachycardia-induced HF to examine global gene expression in left ventricular myocardium with Affymetrix canine oligonucleotide arrays at various stages after initiation of rapid ventricular pacing (days 3, 7, 14, and 21). The gene expression data were complemented with measurements of action potential duration, conduction velocity, and left ventricular end diastolic pressure, and dP/dt(max) over the time course of rapid ventricular pacing. As a result, we present a phenotype-centered gene association network, defining molecular systems that correspond temporally to hemodynamic and electrical remodeling processes. Gene Ontology analysis revealed an orchestrated regulation of oxidative phosphorylation, ATP synthesis, cell signaling pathways, and extracellular matrix components, which occurred as early as 3 days after the initiation of ventricular pacing, coinciding with the early decline in left ventricular pump function and prolongation of action potential duration. The development of clinically overt left ventricular dysfunction was associated with few additional changes in the myocardial transcriptome. We conclude that the majority of tachypacing-induced transcriptional changes occur early after initiation of rapid ventricular pacing. As the transition to overt HF is characterized by few additional transcriptional changes, posttranscriptional modifications may be more critical in regulating myocardial structure and function during later stages of HF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.