ArticleGenetics2008
Positive selection at the binding sites of the male-specific lethal complex involved in dosage compensation in Drosophila.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Intermolecular Interactions Drive Protein Adaptive and Coadaptive Evolution at Both Species and Population Levels.Molecular biology and evolution · 2022Article
- Rapid Evolution of Autosomal Binding Sites of the Dosage Compensation Complex inFrontiers in genetics · 2021Article
- The Effect of Hybridization on Dosage Compensation in Member Species of the Anopheles gambiae Species Complex.Genome biology and evolution · 2018Article
- GFZF, a GlutathioneMolecular and cellular biology · 2018Article
- Evolution of dosage compensation under sexual selection differs between X and Z chromosomes.Nature communications · 2015Article
- Recurrent turnover of chromosome-specific satellites in Drosophila.Genome biology and evolution · 2014Article
- Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila.Genes & development · 2013Article
- Faster-X evolution of gene expression in Drosophila.PLoS genetics · 2012Article
- msl2 mRNA is bound by free nuclear MSL complex in Drosophila melanogaster.Nucleic acids research · 2011Article
- Does positive selection drive transcription factor binding site turnover? A test with Drosophila cis-regulatory modules.PLoS genetics · 2011Article
- Third chromosome candidate genes for conspecific sperm precedence between D. simulans and D. mauritiana.BMC genetics · 2010Article
- A sequence motif enriched in regions bound by the Drosophila dosage compensation complex.BMC genomics · 2010Article
- Genetic testing of the hypothesis that hybrid male lethality results from a failure in dosage compensation.Genetics · 2010Article
- Drosophila dosage compensation: a complex voyage to the X chromosome.Development (Cambridge, England) · 2009Review
- Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities.Science (New York, N.Y.) · 2009Article
- Progress and prospects toward our understanding of the evolution of dosage compensation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Review
- A surrogate approach to study the evolution of noncoding DNA elements that organize eukaryotic genomes.The Journal of heredityReview
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1 author.
Funding
Abstract
In many taxa, males and females differ with respect to their sex chromosomes, and dosage compensation mechanisms have evolved to equalize X-linked gene transcription. In Drosophila, the male-specific lethal (MSL) complex binds to hundreds of sites along the male X chromosome and mediates twofold hypertranscription of the single male X. Two recent studies found evidence for lineage-specific adaptive evolution in all five core protein-coding genes of the MSL complex in Drosophila melanogaster. In particular, dramatic positive selection was detected in domains shown to be responsible for their specific targeting to the X chromosome. Here I use population genetics to show that three previously characterized MSL-binding DNA segments on the X themselves underwent adaptive evolution in D. melanogaster, but not in its close relatives D. simulans and D. yakuba. MSL components have been shown to not correctly target the D. melanogaster X chromosome in hybrids between D. melanogaster and D. simulans. My finding supports the idea of selection-driven coevolution among DNA-protein interactions of the dosage compensation machinery and suggests that misregulated dosage compensation could contribute to male hybrid inviability in Drosophila.
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