ArticleGenetics2008
On the detection of imprinted quantitative trait loci in line crosses: effect of linkage disequilibrium.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Scanning the genomes of parents for imprinted loci acting in their un-genotyped progeny.Scientific reports · 2019Article
- A GWAS assessment of the contribution of genomic imprinting to the variation of body mass index in mice.BMC genomics · 2015Article
- Transcriptome-wide investigation of genomic imprinting in chicken.Nucleic acids research · 2014Article
- Quantitative trait loci affecting response to crowding stress in an F(2) generation of rainbow trout produced through phenotypic selection.Marine biotechnology (New York, N.Y.) · 2013Article
- Genomic imprinting and parent-of-origin effects on complex traits.Nature reviews. Genetics · 2013Review
- Epigenetics and phenotypic variability: some interesting insights from birds.Genetics, selection, evolution : GSE · 2013Review
- Genomic imprinting and genetic effects on muscle traits in mice.BMC genomics · 2012Article
- Article
- A computational framework for the inheritance pattern of genomic imprinting for complex traits.Briefings in bioinformatics · 2012Article
- Article
- Number and mode of inheritance of QTL influencing backfat thickness on SSC2p in Sino-European pig pedigrees.Genetics, selection, evolution : GSE · 2011Article
- Article
- Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits.Frontiers in genetics · 2011Article
- Joint QTL analysis of three connected F2-crosses in pigs.Genetics, selection, evolution : GSE · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imprinted quantitative trait loci (QTL) are commonly reported in studies using line-cross designs, especially in livestock species. It was previously shown that such parent-of-origin effects might result from the nonfixation of QTL alleles in one or both parental lines, rather than from genuine molecular parental imprinting. We herein demonstrate that if linkage disequilibrium exists between marker loci and nonfixed QTL, spurious detection of pseudo-imprinting is increased by an additional 40-80% in scenarios mimicking typical livestock situations. This is due to the fact that imprinting can be tested only in F(2) offspring whose sire and dam have distinct marker genotypes. In the case of linkage disequilibrium between markers and QTL, such parents have a higher chance to have distinct QTL genotypes as well, thus resulting in distinct padumnal and madumnal allele substitution effects, i.e., QTL pseudo-imprinting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.