ArticleUrological research2008
Protein content of human apatite and brushite kidney stones: significant correlation with morphologic measures.
Article in Urological research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Roles of osteopontin gene polymorphism (rs1126616), osteopontin levels in urine and serum, and the risk of urolithiasis: a meta-analysis.BioMed research international · 2015Pooled it
- Effects of Polyphenolic Extracts From Sumac, Pomegranate Peel, Indian Almond Leaves, Falsa, and Banana Bracts on Calcium Oxalate and Brushite Crystallization In Vitro.Chemistry & biodiversity · 2025Article
- Kidney stone growth through the lens of Raman mapping.Scientific reports · 2024Article
- Stone Morphology Distinguishes Two Pathways of Idiopathic Calcium Oxalate Stone Pathogenesis.Journal of endourology · 2022Article
- Multimodal imaging reveals a unique autofluorescence signature of Randall's plaque.Urolithiasis · 2021Article
- Using micro computed tomographic imaging for analyzing kidney stones.Comptes rendus. Chimie (Print) · 2021Article
- Association Between Randall's Plaque Stone Anchors and Renal Papillary Pits.Journal of endourology · 2019Article
- Papillary Ductal Plugging is a Mechanism for Early Stone Retention in Brushite Stone Disease.The Journal of urology · 2018Article
- Integration and utilization of modern technologies in nephrolithiasis research.Nature reviews. Urology · 2016Review
- Dual-Energy CT for Quantification of Urinary Stone Composition in Mixed Stones: A Phantom Study.AJR. American journal of roentgenology · 2016Article
- Micro-CT imaging of Randall's plaques.Urolithiasis · 2015Article
- Impact of urinary stone volume on computed tomography stone attenuations measured in Hounsfield units in a large group of Austrian patients with urolithiasis.Central European journal of urology · 2014Article
- High carbonate level of apatite in kidney stones implies infection, but is it predictive?Urolithiasis · 2013Article
- The establishment of a standard and real patient kidney stone library utilizing Fourier transform-infrared spectroscopy with a diamond ATR accessory.Urological research · 2012Article
- Fragility of brushite stones in shock wave lithotripsy: absence of correlation with computerized tomography visible structure.The Journal of urology · 2012Article
- Stability of the infection marker struvite in urinary stone samples.Journal of endourology · 2012Article
- Investigation of the microstructure and mineralogical composition of urinary calculi fragments by synchrotron radiation X-ray microtomography: a feasibility study.Urological research · 2011Article
- Micro-computed tomography for analysis of urinary calculi.Urological research · 2010Review
- Analysis of mixed stones is prone to error: a study with US laboratories using micro CT for verification of sample content.Urological research · 2010Article
- Detection of different kidney stone types: an ex vivo comparison of ultrashort echo time MRI to reference standard CT.Clinical imagingArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Apatite and brushite kidney stones share calcium and phosphate as their main inorganic components. We tested the hypothesis that these stone types differ in the amount of proteins present in the stones. Intact stones were intensively analyzed by microcomputed tomography (micro CT) for both morphology (including the volume of voids, i.e., space devoid of X-ray dense material) and mineral type. To extract all proteins present in kidney stones in soluble form we developed a three-step extraction procedure using the ground stone powder. Apatite stones had significantly higher levels of total protein content and void volume compared to brushite stones. The void volume was highly correlated with the total protein contents in all stones (r2 = 0.61, P < 0.0001), and brushite stones contained significantly fewer void regions and proteins than did apatite stones (3.2 +/- 4.5% voids for brushite vs. 10.8 +/- 11.2% for apatite, P < 0.005; 4.1 +/- 1.6% protein for brushite vs. 6.0 +/- 2.4% for apatite, P < 0.03). Morphological observations other than void volume did not correlate with protein content of stones, and neither did the presence or absence of minor mineral components. Our results show that protein content of brushite and apatite stones is higher than that was previously thought, and also suggest that micro CT-visible void regions are related to the presence of protein.
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