ArticlePloS one2008
Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- The Role of Notch Signaling and Gut Microbiota in Autoinflammatory Diseases: Mechanisms and Future Views.Biomedicines · 2025Review
- Gut microbiota dysbiosis and associated immune response in systemic lupus erythematosus: impact of disease and treatment.Gut pathogens · 2025Article
- Impact of celiac disease on patients with familial Mediterranean fever: a nationwide study based on the Türkiye database.Frontiers in immunology · 2025Article
- Probiotic Therapy During Vaccination Alters Antibody Response to Simian-Human Immunodeficiency Virus Infection But Not to Commensals.AIDS research and human retroviruses · 2023Article
- Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF).Genes · 2020Review
- Emergence and significance of carbohydrate-specific antibodies.Genes and immunity · 2020Review
- Recurrent pregnancy loss is associated to leaky gut: a novel pathogenic model of endometrium inflammation?Journal of translational medicine · 2018Article
- ProbioticFrontiers in immunology · 2018Article
- Systemic Concentrations of Short Chain Fatty Acids Are Elevated in Salmonellosis and Exacerbation of Familial Mediterranean Fever.Frontiers in microbiology · 2016Article
- The multifaceted role of commensal microbiota in homeostasis and gastrointestinal diseases.Journal of immunology research · 2015Review
- Association of levels of antibodies from patients with inflammatory bowel disease with extracellular proteins of food and probiotic bacteria.BioMed research international · 2014Article
- Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome.Frontiers in cellular and infection microbiology · 2013Article
- Probiotics, prebiotics, and synbiotics: gut and beyond.Gastroenterology research and practice · 2012Article
- Profiles of Microbial Fatty Acids in the Human Metabolome are Disease-Specific.Frontiers in microbiology · 2010Article
- Does breast-feeding affect severity of familial Mediterranean fever?Clinical rheumatology · 2009Article
- Classification ofGut microbesArticle
- Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFamilial Mediterranean fever (FMF) is an autoinflammatory condition, which is characterized by acute, self-limiting episodes of fever and serositis and chronic subclinical inflammation in remission. Here we investigated the consequence of this condition on the level of systemic antibodies directed towards common intestinal bacteria. METHODOLOGY/PRINCIPAL
findingsThe level of systemic antibodies towards the antigens of Bacteroides, Parabacteroides, Escherichia, Enteroccocus and Lactobaccilus was measured by ELISA in FMF patients at various stages of the disease and in healthy controls. The difference between remission and attack was not significant. IgG antibodies against the antigens of Bacteroides, Parabacteroides, Escherichia and Enteroccocus were significantly increased in FMF compared to control while IgA levels were not significantly affected. Western blot analyses demonstrated the IgG reactivity against multiple antigens of commensal bacteria in FMF. Serological expression cloning was performed to identify these antigens. No single dominant antigen was identified; the response was generalized and directed against a variety of proteins from Bacteroides, Parabacteroides, Escherichia, and other gut commensals. CONCLUSIONS/SIGNIFICANCE: This autoinflammatory syndrome is characterized by the increased systemic reactivity against commensal gut microbiota. This is probably the consequence of hypersensitivity of the inflammasome in FMF that triggers the inflammation and contributes to the excessive translocation of bacteria and bacterial antigens through the gut barrier.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.