ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2008
Performance of BRCA1/2 mutation prediction models in Asian Americans.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 67 citations in OpenAlex.
- Performance of prediction models for BRCA mutation carriage in three racial/ethnic groups: findings from the Northern California Breast Cancer Family Registry.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Trial
- Exploring Traditional Breast Cancer Risk Genes Among Aboriginal and Torres Strait Islander Women.Life (Basel, Switzerland) · 2026Article
- Development of a novel prediction model for carriage of BRCA1/2 pathogenic variant in Japanese patients with breast cancer based on Japanese organization of hereditary breast and ovarian cancer registry data.Breast cancer research and treatment · 2025Article
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- Chinese American and Non-Hispanic White Breast Cancer Patients' Knowledge and Use of BRCA Testing.International journal of environmental research and public health · 2023Article
- Analysis of Breast Cancer Differences between China and Western Countries Based on Radiogenomics.Genes · 2022Article
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- Predicting the Likelihood of Carrying aJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Article
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- BRCA and Breast Cancer-Related High-Penetrance Genes.Advances in experimental medicine and biology · 2021Review
- Risks of Second Primary Gynecologic Cancers following Ovarian Cancer Treatment in Asian Ethnic Subgroups in the United States, 2000-2016.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Recurrent BRCA1 Mutation, but no BRCA2 Mutation, in Vietnamese Patients with Ovarian Carcinoma Detected with Next Generation Sequencing.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Evaluating BRCA mutation risk predictive models in a Chinese cohort in Taiwan.Scientific reports · 2019Article
- Article
- Cancer genetic counseling communication with low-income Chinese immigrants.Journal of community genetics · 2018Article
- Multicenter cross-sectional screening of theOncology letters · 2018Article
- Racial/ethnic differences in multiple-gene sequencing results for hereditary cancer risk.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Article
- Inherited mutations inJournal of medical genetics · 2018Article
- Rapid detection ofOncotarget · 2018Article
- Article
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15 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThere are established differences in breast cancer epidemiology between Asian and white individuals, but little is known about hereditary breast cancer in Asian populations. Although increasing numbers of Asian individuals are clinically tested for BRCA1/2 mutations, it is not known whether computer models that predict mutations work accurately in Asian individuals. We compared the performance in Asian and white individuals of two widely used BRCA1/2 mutation prediction models, BRCAPRO and Myriad II. PATIENTS AND
methodsWe evaluated BRCAPRO and Myriad II in 200 Asian individuals and a matched control group of 200 white individuals who were tested for BRCA1/2 mutations at four cancer genetics clinics, by comparing numbers of observed versus predicted mutation carriers and by evaluating area under the receiver operating characteristic curve (AUC) for each model.
resultsBRCAPRO and Myriad II accurately predicted the number of white BRCA1/2 mutation carriers (25 observed v 24 predicted by BRCAPRO; 25 predicted by Myriad II, P > or = .69), but underpredicted Asian carriers by two-fold (49 observed v 25 predicted by BRCAPRO; 26 predicted by Myriad II; P < or = 3 x 10(-7)). For BRCAPRO, this racial difference reflects substantial underprediction of Asian BRCA2 mutation carriers (26 observed v 4 predicted; P = 1 x 10(-30)); for Myriad II, separate mutation predictions were not available. For both models, AUCs were nonsignificantly lower in Asian than white individuals, suggesting less accurate discrimination between Asian carriers and noncarriers.
conclusionBoth BRCAPRO and Myriad II underestimated the proportion of BRCA1/2 mutation carriers, and discriminated carriers from noncarriers less well, in Asian compared with white individuals.
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