ReviewBiochimica et biophysica acta2009
Structure and evolution of the C. elegans embryonic endomesoderm network.
Review in Biochimica et biophysica acta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Maternal histone methyltransferases antagonistically regulate autosomal random monoallelic expression (aRMAE) in C. elegans.Nature communications · 2025Article
- Evolutionary Change in Gut Specification inJournal of developmental biology · 2023Review
- Review
- A developmental gene regulatory network forDevelopment (Cambridge, England) · 2020Article
- From "the Worm" to "the Worms" and Back Again: The Evolutionary Developmental Biology of Nematodes.Genetics · 2018Review
- Understanding transcriptional regulatory networks using computational models.Current opinion in genetics & development · 2016Review
- Convergent occurrence of the developmental hourglass in plant and animal embryogenesis?Annals of botany · 2016Review
- Article
- MED GATA factors promote robust development of the C. elegans endoderm.Developmental biology · 2015Article
- E3 ubiquitin ligases promote progression of differentiation during C. elegans embryogenesis.Developmental biology · 2015Article
- Dose-dependent nuclear β-catenin response segregates endomesoderm along the sea star primary axis.Development (Cambridge, England) · 2015Article
- Article
- TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development.Developmental biology · 2013Article
- Collaborative regulation of development but independent control of metabolism by two epidermis-specific transcription factors in Caenorhabditis elegans.The Journal of biological chemistry · 2013Article
- Article
- Cleavage pattern and fate map of the mesentoblast, 4d, in the gastropod Crepidula: a hallmark of spiralian development.EvoDevo · 2012Article
- Initial deployment of the cardiogenic gene regulatory network in the basal chordate, Ciona intestinalis.Developmental biology · 2012Article
- A framework for the establishment of a cnidarian gene regulatory network for "endomesoderm" specification: the inputs of ß-catenin/TCF signaling.PLoS genetics · 2012Article
- Review
- Roles of the Wnt effector POP-1/TCF in the C. elegans endomesoderm specification gene network.Developmental biology · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The specification of the Caenorhabditis elegans endomesoderm has been the subject of study for more than 15 years. Specification of the 4-cell stage endomesoderm precursor, EMS, occurs as a result of the activation of a transcription factor cascade that starts with SKN-1, coupled with input from the Wnt/beta-catenin asymmetry pathway through the nuclear effector POP-1. As development proceeds, transiently-expressed cell fate factors are succeeded by stable, tissue/organ-specific regulators. The pathway is complex and uses motifs found in all transcriptional networks. Here, the regulators that function in the C. elegans endomesoderm network are described. An examination of the motifs in the network suggests how they may have evolved from simpler gene interactions. Flexibility in the network is evident from the multitude of parallel functions that have been identified and from apparent changes in parts of the corresponding network in Caenorhabditis briggsae. Overall, the complexities of C. elegans endomesoderm specification build a picture of a network that is robust, complex, and still evolving.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.