ReviewCurrent opinion in neurobiology2008
Action in the axon: generation and transport of signaling endosomes.
Review in Current opinion in neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
81 citing papers in PubMed.
- Article
- Review
- Communicating pain: emerging axonal signaling in peripheral neuropathic pain.Frontiers in neuroanatomy · 2024Review
- Review
- Brain Exosomes: Friend or Foe in Alzheimer's Disease?Molecular neurobiology · 2021Review
- Cleavage of human tau at Asp421 inhibits hyperphosphorylated tau induced pathology in a Drosophila model.Scientific reports · 2020Article
- (H)Elping nerve growth factor: Elp1 inhibits TrkA's phosphatase to maintain retrograde signaling.The Journal of clinical investigation · 2020Article
- Neurotrophic effects of GScientific reports · 2020Article
- Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway.Scientific reports · 2020Article
- Target-Derived Neurotrophic Factor Deprivation Puts Retinal Ganglion Cells on Death Row: Cold Hard Evidence and Caveats.International journal of molecular sciences · 2019Review
- Neural control of body-plan axis in regenerating planaria.PLoS computational biology · 2019Article
- Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells.The Journal of cell biology · 2018Article
- Retrograde influences of SCG axotomy on uninjured preganglionic neurons.Brain research · 2018Article
- Article
- Ceramide and Exosomes: A Novel Target in Cancer Biology and Therapy.Advances in cancer research · 2018Review
- Glaucoma Pathogenesis and Neurotrophins: Focus on the Molecular and Genetic Basis for Therapeutic Prospects.Current neuropharmacology · 2018Review
- Retrograde apoptotic signaling by the p75 neurotrophin receptor.Neuronal signaling · 2017Review
- Regulation of dendritic development by semaphorin 3A through novel intracellular remote signaling.Cell adhesion & migration · 2016Review
- Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics.Marine drugs · 2016Review
- Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons.Development (Cambridge, England) · 2016Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Neurons extend axonal processes over long distances, necessitating efficient transport mechanisms to convey target-derived neurotrophic survival signals from remote distal axons to cell bodies. Retrograde transport, powered by dynein motors, supplies cell bodies with survival signals in the form of 'signaling endosomes'. In this review, we will discuss new advances in our understanding of the motor proteins that bind to and move signaling components in a retrograde direction and discuss mechanisms that might specify distinct neuronal responses to spatially restricted neurotrophin signals. Disruption of retrograde transport leads to a variety of neurodegenerative diseases, highlighting the role of retrograde transport of signaling endosomes for axonal maintenance and the importance of efficient transport for neuronal survival and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.