ReviewMutation research2008
Genomic imprinting mechanisms in mammals.
Review in Mutation research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 296 citations in OpenAlex.
- Article
- Candidate imprinting control regions in dog genome.BMC genomics · 2025Article
- Establishing extended pluripotent stem cells from human urine cells.Cell & bioscience · 2023Article
- Defining Candidate Imprinted loci inGenes · 2023Article
- Epigenetic Reprogramming and Somatic Cell Nuclear Transfer.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA.eLife · 2021Article
- Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart.Frontiers in cell and developmental biology · 2021Article
- Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function.PLoS genetics · 2020Article
- Epigenetic transgenerational inheritance of parent-of-origin allelic transmission of outcross pathology and sperm epimutations.Developmental biology · 2020Article
- Role of genomic imprinting in mammalian development.Journal of biosciences · 2020Review
- Maternal Microdeletion at theEpigenetics insights · 2020Article
- DNA methylation, environmental exposures and early embryo development.Animal reproduction · 2019Article
- Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss.Human molecular genetics · 2019Article
- Paternal bias expression of Igf2as is enhancer-dependent on the imprinting cluster of Igf2, H19 and Nctc1 in muscle cells.Animal cells and systems · 2019Article
- Longitudinal personal DNA methylome dynamics in a human with a chronic condition.Nature medicine · 2018Article
- Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome.Disease models & mechanisms · 2018Article
- Loss of imprinting mutations define both distinct and overlapping roles for misexpression of IGF2 and of H19 lncRNA.Nucleic acids research · 2017Article
- Chromosome choice for initiation of V-(D)-J recombination is not governed by genomic imprinting.Immunology and cell biology · 2017Article
- Genomic imprinting, disrupted placental expression, and speciation.Evolution; international journal of organic evolution · 2016Article
- Selection-, age-, and exercise-dependence of skeletal muscle gene expression patterns in a rat model of metabolic fitness.Physiological genomics · 2016Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Genomic imprinting is a form of epigenetic gene regulation that results in expression from a single allele in a parent-of-origin-dependent manner. This form of monoallelic expression affects a small but growing number of genes and is essential to normal mammalian development. Despite extensive studies and some major breakthroughs regarding this intriguing phenomenon, we have not yet fully characterized the underlying molecular mechanisms of genomic imprinting. This is in part due to the complexity of the system in that the epigenetic markings required for proper imprinting must be established in the germline, maintained throughout development, and then erased before being re-established in the next generation's germline. Furthermore, imprinted gene expression is often tissue or stage-specific. It has also become clear that while imprinted loci across the genome seem to rely consistently on epigenetic markings of DNA methylation and/or histone modifications to discern parental alleles, the regulatory activities underlying these markings vary among loci. Here, we discuss different modes of imprinting regulation in mammals and how perturbations of these systems result in human disease. We focus on the mechanism of genomic imprinting mediated by insulators as is present at the H19/Igf2 locus, and by non-coding RNA present at the Igf2r and Kcnq1 loci. In addition to imprinting mechanisms at autosomal loci, what is known about imprinted X-chromosome inactivation and how it compares to autosomal imprinting is also discussed. Overall, this review summarizes many years of imprinting research, while pointing out exciting new discoveries that further elucidate the mechanism of genomic imprinting, and speculating on areas that require further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.