ArticleExperimental eye research2008
Localization and regulation of dopamine receptor D4 expression in the adult and developing rat retina.
Article in Experimental eye research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 55 citations in OpenAlex.
- Altered Retinal Dopamine Homeostasis in Murine Models of Retinitis Pigmentosa.Journal of neurochemistry · 2026Article
- IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.Investigative ophthalmology & visual science · 2025Review
- Cyclic nucleotide signaling as a drug target in retinitis pigmentosa.FEBS letters · 2025Review
- Retinal fundus imaging as biomarker for ADHD using machine learning for screening and visual attention stratification.NPJ digital medicine · 2025Article
- Molecular characterization of chicken DA systems reveals that the avian personality gene,Frontiers in neuroanatomy · 2025Article
- Impaired dopamine signaling in early diabetic retina: Insights from D1R and D4R agonist effects on whole retina responses.Experimental eye research · 2024Article
- Pupillary Light Reflex Reveals Melanopsin System Alteration in the Background of Myopia-26, the Female Limited Form of Early-Onset High Myopia.Investigative ophthalmology & visual science · 2024Article
- Humanized dopamine DJournal of neuroscience research · 2024Review
- Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function.Progress in retinal and eye research · 2023Review
- Variation in the Dopamine-4-Receptor Gene in Patients with Type 1 Diabetes.Neuroendocrinology · 2023Article
- Impaired Light Adaptation of ON-Sustained Ganglion Cells in Early Diabetes Is Attributable to Diminished Response to Dopamine D4 Receptor Activation.Investigative ophthalmology & visual science · 2022Article
- Functional and pharmacological role of the dopamine DFrontiers in endocrinology · 2022Review
- Depletion of Retinal Dopaminergic Activity in a Mouse Model of Rod Dysfunction Exacerbates Experimental Autoimmune Uveoretinitis: A Role for the Gateway Reflex.International journal of molecular sciences · 2021Article
- Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells.Journal of neurophysiology · 2021Article
- The Circadian Oscillator of the Cerebellum: Triiodothyronine Regulates Clock Gene Expression in Granule CellsFrontiers in physiology · 2021Article
- Effects of Cone Connexin-36 Disruption on Light Adaptation and Circadian Regulation of the Photopic ERG.Investigative ophthalmology & visual science · 2020Article
- Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland.Journal of pineal research · 2020Article
- The Lhx4 homeobox transcript in the rat pineal gland: Adrenergic regulation and impact on transcripts encoding melatonin-synthesizing enzymes.Journal of pineal research · 2020Article
- Effects of time-of-day on inhibition of lens-induced myopia by quinpirole, pirenzepine and atropine in chicks.Experimental eye research · 2019Article
- The effects of dopamine and dopamine receptor agonists on the phototransduction cascade of frog rods.Molecular vision · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Levels of dopamine and melatonin exhibit diurnal rhythms in the rat retina. Dopamine is high during daytime adapting the retina to light, whereas melatonin is high during nighttime participating in the adaptation of the retina to low light intensities. Dopamine inhibits the synthesis of melatonin in the photoreceptors via Drd4 receptors located on the cell membrane of these cells. In this study, we show by semiquantitative in situ hybridization a prominent day/night variation in Drd4 expression in the retina of the Sprague-Dawley rat with a peak during the nighttime. Drd4 expression is seen in all retinal layers but the nocturnal increase is confined to the photoreceptors. Retinal Drd4 expression is not affected by removal of the sympathetic input to the eye, but triiodothyronine treatment induces Drd4 expression in the photoreceptors. In a developmental series, we show that the expression of Drd4 is restricted to postnatal stages with a peak at postnatal day 12. The high Drd4 expression in the rat retinal photoreceptors during the night supports physiological and pharmacologic evidence that the Drd4 receptor is involved in the dopaminergic inhibition of melatonin synthesis upon light stimulation. The sharp increase of Drd4 expression at a specific postnatal time suggests that dopamine is involved in retinal development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.