ArticleBMC medical genetics2008
Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population.
Article in BMC medical genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis.Respiratory research · 2019Pooled it
- ADAM33 polymorphisms and susceptibility to allergic rhinitis: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2015Pooled it
- Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Pooled it
- Asthma susceptible genes in Chinese population: a meta-analysis.Respiratory research · 2010Pooled it
- Association betweenDiagnostics (Basel, Switzerland) · 2023Article
- The Association of IgE Levels withJournal of personalized medicine · 2021Article
- Article
- Association of a disintegrin and metalloprotease 33 gene polymorphisms with asthma.Molecular and clinical oncology · 2014Article
- Genetic polymorphisms and asthma: findings from a case-control study in the Madeira island population.Biological research · 2014Article
- Association study on ADAM33 polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.PloS one · 2014Article
- Poor reproducibility of allergic rhinitis SNP associations.PloS one · 2013Article
- The challenge of asthma in minority populations.Clinical reviews in allergy & immunology · 2012Review
- Association of ADAM33 gene with susceptibility to COPD in Tibetan population of China.Molecular biology reports · 2011Article
- Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population.Journal of genetics · 2011Article
- Role of ADAM33 gene and associated single nucleotide polymorphisms in asthma.Allergy & rhinology (Providence, R.I.) · 2011Article
- Article
- Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study.BMC pulmonary medicine · 2010Article
- Role of ADAM and ADAMTS metalloproteinases in airway diseases.Respiratory research · 2009Review
- Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population.BMC medical genetics · 2009Article
- Analyses of associations between three positionally cloned asthma candidate genes and asthma or asthma-related phenotypes in a Chinese population.BMC medical genetics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRhinitis and asthma are very common diseases involving genetic and environmental factors. Most patients with asthma also have rhinitis, which suggests the concept of 'one airway, one disease.' A disintegrin and metalloproteinase 33 (ADAM33) is the first asthma-susceptible gene to be discovered by positional cloning. To evaluate the potential influence of ADAM33 gene polymorphisms on allergic rhinitis (AR) and allergic asthma (AS), a case-control study was conducted on the Han population of northeast China.
methodsSix polymorphic sites (V4, T+1, T2, T1, S1, and Q-1) were genotyped in 128 patients with AR, 181 patients with AS, and 151 healthy controls (CTR). Genotypes were determined by the polymerase chain restriction fragment length polymorphism (PCR-RFLP) method. Data were analyzed using the chi-square test with Haploview software.
resultsThe single nucleotide polymorphisms (SNPs), V4 G/C, T+1 A/G, and T1 G/A, of the ADAM33 gene may be the causal variants in AR, whereas ADAM33 V4 G/C, T2 A/G, T1 G/A, and Q-1A/G may participate in the susceptibility of AS.
conclusionThese results suggest that polymorphisms of the ADAM33 gene may modify individual susceptibility to AR and AS in a Chinese Han population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.