ArticleParticle and fibre toxicology2008
Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume.
Article in Particle and fibre toxicology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Research recommendations for selected IARC-classified agents.Environmental health perspectives · 2010Pooled it
- Inflammatory Responses to Zn/Cu-Containing Welding Fume in Human Alveolar Epithelial and Macrophage Cell Lines, with MIP-1β/CCL4 as a Much More Sensitive Macrophage Activation Marker than IL-8 and TNF-α.International journal of molecular sciences · 2025Article
- Hepatotoxicity and ALAD Activity Profile for Prediction of NOAEL of Metal Welding Fumes in Albino Rats.Biological trace element research · 2023Article
- The human long noncoding RNAs CoroMarker, MALAT1, CDR1as, and LINC00460 in whole blood of individuals after controlled short-term exposure with ultrafine metal fume particles at workplace conditions, and in human macrophages in vitro.Journal of occupational medicine and toxicology (London, England) · 2022Article
- Lung toxicity profile of inhaled copper-nickel welding fume in A/J mice.Inhalation toxicology · 2022Article
- Toxicity of stainless and mild steel particles generated from gas-metal arc welding in primary human small airway epithelial cells.Scientific reports · 2021Article
- Assessment of particulate matter toxicity and physicochemistry at the Claim 28 uranium mine site in Blue Gap, AZ.Journal of toxicology and environmental health. Part A · 2021Article
- Tumorigenic response in lung tumor susceptible A/J mice after sub-chronic exposure to calcium chromate or iron (III) oxide.Toxicology letters · 2020Article
- Cyanidin-3-Molecules (Basel, Switzerland) · 2020Article
- Influence of welding fume metal composition on lung toxicity and tumor formation in experimental animal models.Journal of occupational and environmental hygiene · 2019Review
- Inhalation of iron-abundant gas metal arc welding-mild steel fume promotes lung tumors in mice.Toxicology · 2018Article
- Article
- Cancer Risks among Welders and Occasional Welders in a National Population-Based Cohort Study: Canadian Census Health and Environmental Cohort.Safety and health at work · 2017Article
- Inhalation of gas metal arc-stainless steel welding fume promotes lung tumorigenesis in A/J mice.Archives of toxicology · 2017Article
- Comment on Shvedova et al. (2016), "gender differences in murine pulmonary responses elicited by cellulose nanocrystals".Particle and fibre toxicology · 2016Article
- Role of metal oxide nanoparticles in histopathological changes observed in the lung of welders.Particle and fibre toxicology · 2014Article
- Evaluation of the Pulmonary Toxicity of a Fume Generated from a Nickel-, Copper-Based Electrode to be Used as a Substitute in Stainless Steel Welding.Environmental health insights · 2014Article
- Article
- Lung tumor promotion by chromium-containing welding particulate matter in a mouse model.Particle and fibre toxicology · 2013Article
- Hexavalent chromium Cr(VI) up-regulates COX-2 expression through an NFκB/c-Jun/AP-1-dependent pathway.Environmental health perspectives · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWelding fume has been categorized as "possibly carcinogenic" to humans. Our objectives were to characterize the lung response to carcinogenic and non-carcinogenic metal-containing welding fumes and to determine if these fumes caused increased lung tumorigenicity in A/J mice, a lung tumor susceptible strain. We exposed male A/J and C57BL/6J, a lung tumor resistant strain, by pharyngeal aspiration four times (once every 3 days) to 85 mug of gas metal arc-mild steel (GMA-MS), GMA-stainless steel (SS), or manual metal arc-SS (MMA-SS) fume, or to 25.5 mug soluble hexavalent chromium (S-Cr). Shams were exposed to saline vehicle. Bronchoalveolar lavage (BAL) was done at 2, 7, and 28 days post-exposure. For the lung tumor study, gross tumor counts and histopathological changes were assessed in A/J mice at 48 and 78 weeks post-exposure.
resultsBAL revealed notable strain-dependent differences with regards to the degree and resolution of the inflammatory response after exposure to the fumes. At 48 weeks, carcinogenic metal-containing GMA-SS fume caused the greatest increase in tumor multiplicity and incidence, but this was not different from sham. By 78 weeks, tumor incidence in the GMA-SS group versus sham approached significance (p = 0.057). A significant increase in perivascular/peribronchial lymphoid infiltrates for the GMA-SS group versus sham and an increased persistence of this fume in lung cells compared to the other welding fumes was found.
conclusionThe increased persistence of GMA-SS fume in combination with its metal composition may trigger a chronic, but mild, inflammatory state in the lung possibly enhancing tumorigenesis in this susceptible mouse strain.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.