ArticleBMC microbiology2008
The PagN protein of Salmonella enterica serovar Typhimurium is an adhesin and invasin.
Article in BMC microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 101 citations in OpenAlex.
- Assessing transcriptomic responses ofMicrobiology spectrum · 2026Article
- The structures and functions of Salmonella outer membrane.Archives of microbiology · 2026Review
- PagN: a multifunctional outer membrane protein in Salmonella virulence and host interaction.Archives of microbiology · 2026Review
- Genomic characterization of a virulent multidrug-resistant Salmonella enterica serovar Enteritidis strain isolated from meat rabbits (Oryctolagus cuniculus) in China.BMC microbiology · 2026Article
- Infection strategies ofGut microbes reports · 2026Review
- TheFEMS microbes · 2026Article
- Harnessing gut microbiota to mitigateVirulence · 2025Review
- Roles and mechanisms ofVirulence · 2025Article
- RegIIIβ promotes Salmonella Typhimurium colonization of the gut in the early-stage gastrointestinal infection by enhancing flagella-driven locomotion.PLoS pathogens · 2025Article
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- Infection biology ofEcoSal Plus · 2024Review
- TheVirulence · 2024Article
- A Systemic Review on Fitness and Survival ofIndian journal of microbiology · 2024Review
- A Review of the Mechanisms of Bacterial Colonization of the Mammal Gut.Microorganisms · 2024Review
- Strategies adopted by Salmonella to survive in host: a review.Archives of microbiology · 2023Review
- Review
- Virulence genes identification inVeterinary world · 2023Article
- Barcoded Consortium Infections: A Scalable, Internally Controlled Method to Study Host Cell Binding and Invasion by Pathogenic Bacteria.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Establishment of indirect ELISA method for Salmonella antibody detection from ducks based on PagN protein.BMC veterinary research · 2022Article
- Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pagN gene of Salmonella enterica serovar Typhimurium is a PhoP-regulated gene that is up-regulated during growth within macrophages and in vivo in murine models of infection. The PagN protein displays similarity to the Hek and Tia invasins/adhesins of Escherichia coli. Thus far no function has been ascribed to the PagN protein.
resultsHere we show that the outer membrane located PagN protein mediates agglutination of red blood cells and that this can be masked by LPS. When expressed in Escherichia coli the PagN protein supports adhesion to and invasion of mammalian cells in a manner that is dependent on cytoskeletal rearrangements. S. enterica sv Typhimurium pagN mutants display a reduction in adhesion to and invasion of epithelial cells. Finally, we demonstrate that over-expression of PagN in a SPI-1 mutant can partially compensate for the lack of a functional invasasome.
conclusionPagN is an outer membrane protein that may contribute to the virulence of S. Typhimurium. This protein is a haemagglutinin and contributes to the adherence to mammalian cells. In addition, PagN can mediate high-level invasion of CHO-K1 cells. Previously,pagN mutants have been shown to be less competitive in vivo and thus this may be due to their lessened ability to interact with mammalian cells. Finally PagN can be added to an ever-growing repertoire of factors that contribute to the pathogenesis of Salmonella.
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