ArticleWorld journal of gastroenterology2008
Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies.Nutrients · 2017Pooled it
- Investigating Network and Experimental Effect of Silibinin on Lipin-1 and Lipin-2 Gene Expression during Ischemia-reperfusion of the Liver in Rats.Cell biochemistry and biophysics · 2025Article
- Comprehensive and updated review on anti-oxidant effects ofIranian journal of basic medical sciences · 2024Review
- Effect of thymoquinone on transient receptor potential melastatin (TRPM) channels in rats with liver ischemia reperfusion model in rats.Iranian journal of basic medical sciences · 2024Article
- Effect ofFrontiers in veterinary science · 2022Article
- Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Dissecting the Potential Roles ofFrontiers in aging neuroscience · 2018Review
- The Ameliorative Effects of PycnogenolTurkish journal of pharmaceutical sciences · 2017Article
- Nigella Sativa Oil Protects the Rat Ovary from Oxidative Injury Due to Ischemia-Reperfusion.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Thymoquinone mitigate ischemia-reperfusion-induced liver injury in rats: a pivotal role of nitric oxide signaling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- SELECTIVE INHIBITION OF HEPATITIS C VIRUS REPLICATION BY ALPHA-ZAM, AAfrican journal of traditional, complementary, and alternative medicines : AJTCAM · 2016Article
- Updates in diagnosis and management of Ebola hemorrhagic fever.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Review
- New Horizons in Enhancing the Proliferation and Differentiation of Neural Stem Cells Using Stimulatory Effects of the Short Time Exposure to Radiofrequency Radiation.Journal of biomedical physics & engineering · 2015Review
- Effect of Nigella sativa on ischemia-reperfusion induced rat kidney damage.Iranian journal of basic medical sciences · 2014Article
- The protective effect of Nigella sativa against liver injury: a review.Iranian journal of basic medical sciences · 2014Review
- Some mechanisms of the protective effect of ischemic preconditioning on rat liver ischemia-reperfusion injury.International journal of general medicine · 2014Article
- A review of hepatoprotective plants used in saudi traditional medicine.Evidence-based complementary and alternative medicine : eCAM · 2014Review
- Nigella sativa attenuates myocardial ischemic reperfusion injury in rats.Journal of physiology and biochemistry · 2013Article
- A review on therapeutic potential of Nigella sativa: A miracle herb.Asian Pacific journal of tropical biomedicine · 2013Review
- Effects of Nigella sativa on outcome of hepatitis C in Egypt.World journal of gastroenterology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine whether Nigella sativa prevents hepatic ischemia-reperfusion injury to the liver.
methodsThirty rats were divided into three groups as sham (Group 1), control (Group 2), and Nigella sativa (NS) treatment group (Group 3). All rats underwent hepatic ischemia for 45 min followed by 60 min period of reperfusion. Rats were intraperitoneally infused with only 0.9% saline solution in group 2. Rats in group 3 received NS (0.2 mL/kg) intraperitoneally, before ischemia and before reperfusion. Blood samples and liver tissues were harvested from the rats, and then the rats were sacrificed. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined. Total antioxidant capacity (TAC), catalase (CAT), total oxidative status (TOS), oxidative stress index (OSI) and myeloperoxidase (MPO) in hepatic tissue were measured. Also liver tissue histopathology was evaluated by light microscopy.
resultsThe levels of liver enzymes in group 3 were significantly lower than those in the group 2. TAC in liver tissue was significantly higher in group 3 than in group 2. TOS, OSI and MPO in hepatic tissue were significantly lower in group 3 than the group 2. Histological tissue damage was milder in the NS treatment group than that in the control group.
conclusionOur results suggest that Nigella sativa treatment protects the rat liver against to hepatic ischemia-reperfusion injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.