ArticleWorld journal of gastroenterology2008
Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Effects of ketamine on penile tissues in an experimental priapism model in rats.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024Article
- Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studies.Frontiers in pharmacology · 2024Review
- Protective Effect of Oxygen and Isoflurane in Rodent Model of Intestinal Ischemia-Reperfusion Injury.International journal of molecular sciences · 2023Article
- Simvastatin nanoparticles attenuated intestinal ischemia/reperfusion injury by downregulating BMP4/COX-2 pathway in rats.International journal of nanomedicine · 2017Article
- Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model.Oxidative medicine and cellular longevity · 2015Article
- Protective effects of intravenous anesthetics on kidney tissue in obstructive jaundice.World journal of gastroenterology · 2014Article
- The effect of intravenous anesthetics on ischemia-reperfusion injury.BioMed research international · 2014Review
- Intestinal injury can be reduced by intra-arterial postischemic perfusion with hypertonic saline.World journal of gastroenterology · 2013Article
- Effects of ketamine on endotoxin and traumatic brain injury induced cytokine production in the rat.The Journal of trauma · 2011Article
- Effects of penehyclidine hydrochloride in small intestinal damage caused by limb ischemia-reperfusion.World journal of gastroenterology · 2011Article
- Comparative effects of triflusal, S-adenosylmethionine, and dextromethorphan over intestinal ischemia/reperfusion injury.TheScientificWorldJournal · 2011Article
- Ketamine reduces intestinal injury and inflammatory cell infiltration after ischemia/reperfusion in rats.Surgery today · 2010Article
- Ketamine and the myenteric plexus in intestinal ischemia/reperfusion injury.Digestive diseases and sciences · 2010Article
- Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With Colic.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats.
methodsThirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by obstructing blood flow in 25% of the total small intestinal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pentobarbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for morphological alterations, and after 24 h intestinal basic electrical rhythm (BER) frequency was calculated, and intestinal transit determined in all groups.
resultsThe intestinal mucosa in rats that were anesthetized with ketamine showed moderate alterations such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pentobarbital sodium after 60 min of reperfusion. Quantitative analysis of structural damage using the Chiu scale showed significantly less injury in rats that received ketamine than in rats that did not (2.35+/-1.14 vs 4.58+/-0.50, P<0.0001). The distance traveled by a marker, expressed as percentage of total intestinal length, in rats that received pentobarbital sodium was 20%+/-2% in comparison with 25.9%+/-1.64% in rats that received ketamine (P=0.017). BER was not statistically different between groups.
conclusionOur results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion.
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