ReviewSeminars in neurology2008
Teratogenicity of antiepileptic medications.
Review in Seminars in neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2011Pooled it
- An In Vivo and In Silico Approach Reveals Possible Sodium Channel Nav1.2 Inhibitors fromBrain sciences · 2024Article
- Adherence of Saudi women with epilepsy to folic acid intake in the preconceptional period in two tertiary care hospitals in Riyadh: A cross sectional study.Epilepsy & behavior reports · 2022Article
- Gene Environment Interactions in the Etiology of Neural Tube Defects.Frontiers in genetics · 2021Review
- Inhibition of Valproic Acid-Induced Prenatal Developmental Abnormalities with Antioxidants in Rats.ACS omega · 2020Article
- The Effect of Voluntary Exercise and Prenatal Exposure to Sodium Valproate on Learning, Memory, and Anxiety of Rats' Offspring.Iranian journal of medical sciences · 2020Article
- Fetal antiepileptic drug exposure: Adaptive and emotional/behavioral functioning at age 6years.Epilepsy & behavior : E&B · 2013Article
- Exposure to antiepileptic drugs in utero and child development: a prospective population-based study.Epilepsia · 2013Article
- The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing.Epigenetics & chromatin · 2013Article
- Article
- Fetal antiepileptic drug exposure: motor, adaptive, and emotional/behavioral functioning at age 3 years.Epilepsy & behavior : E&B · 2011Article
- A head-to-head comparison of risperidone and divalproex for treatment of pediatric bipolar disorder.Current psychiatry reports · 2011Article
- Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of age.Brain : a journal of neurology · 2011Article
- Chromatin modifying agents in the in vitro production of bovine embryos.Veterinary medicine international · 2010Article
- Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Review
- Iniencephaly: Case Report.Journal of pediatric neurosciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Antiepileptic drugs (AEDs) are frequently used to treat several conditions that are common in women of childbearing age, including epilepsy, headaches, and mood disorders. Moreover, as in the case of epilepsy and severe psychiatric disease, clinicians frequently do not have the option of stopping these medications or switching to another class of drugs. Overall, AEDs have been associated with an increased risk of major congenital malformations, minor anomalies, specific congenital syndromes, and developmental disorders seen in childhood. However, the differential effects of individual AEDs remain uncertain. Data are accumulating which strongly suggest that these risks are highest in patients receiving polypharmacy and valproate. There is also modest evidence to suggest an increased risk for phenobarbital. While other older AEDs appear to carry some teratogenic risk, there is not adequate evidence to further stratify their risk. Clinical and basic science research regarding newer AEDs suggests equivalent, if not safer, profiles compared with older AEDs, but these data are inconclusive. Management of women with epilepsy should include a discussion of these risks, prophylactic treatment with folic acid, and the minimal use of polypharmacy and valproate needed to maintain optimum seizure control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.