ArticleMolecular and cellular biochemistry2009
Notch signaling regulates the FOXP3 promoter through RBP-J- and Hes1-dependent mechanisms.
Article in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Pharmacological mechanisms of traditional Chinese medicine metabolites in regulating Treg cells: an integrative pathway review.Frontiers in pharmacology · 2025Review
- Review
- FOXP3 knockdown inhibits the proliferation and reduces NOTCH1 expression of T cell acute lymphoblastic leukemia cells.BMC research notes · 2018Article
- FOXP3 expression is modulated by TGF‑β1/NOTCH1 pathway in human melanoma.International journal of molecular medicine · 2018Article
- Deficient O-GlcNAc Glycosylation Impairs Regulatory T Cell Differentiation and Notch Signaling in Autoimmune Hepatitis.Frontiers in immunology · 2018Article
- Phosphatase and tensin homolog-β-catenin signaling modulates regulatory T cells and inflammatory responses in mouse liver ischemia/reperfusion injury.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2017Article
- Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Notch Signaling in T Helper Cell Subsets: Instructor or Unbiased Amplifier?Frontiers in immunology · 2017Review
- Notch signalling suppresses regulatory T-cell function in murine experimental autoimmune uveitis.Immunology · 2016Article
- Notch Signaling and Immune Regulation in Alloimmunity.Current transplantation reports · 2016Article
- Decidual vascular endothelial cells promote maternal-fetal immune tolerance by inducing regulatory T cells through canonical Notch1 signaling.Immunology and cell biology · 2016Article
- Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus.Results in immunology · 2016Article
- Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.Nature immunology · 2015Article
- Targeting Notch signaling by γ-secretase inhibitor I enhances the cytotoxic effect of 5-FU in gastric cancer.Clinical & experimental metastasis · 2015Article
- A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis Mediated Through FoxP3+ CD8 T Cells.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- T-regulatory cell-mediated immune tolerance as a potential immunotherapeutic strategy to facilitate graft survival.Blood transfusion = Trasfusione del sangue · 2013Review
- T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Notch1 signaling is involved in regulating Foxp3 expression in T-ALL.Cancer cell international · 2013Article
- Protein hairy enhancer of split-1 expression during differentiation of muscle-derived stem cells into neuron-like cells.Neural regeneration research · 2012Article
- Molecular mechanisms underlying the regulation and functional plasticity of FOXP3(+) regulatory T cells.Genes and immunity · 2012Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence has shown that Notch signaling modulates CD4(+)CD25(+) regulatory T-cells (Tregs). As transcription factor Foxp3 acts as a master molecule governing the development and function of Tregs, we investigated whether Notch signaling might directly regulate Foxp3 expression. Here, we provide evidence that Notch signaling can modulate the FOXP3 promoter through RBP-J- and Hes1-dependent mechanisms. A conserved RBP-J-binding site and N-box sites were identified within the FOXP3 promoter. We show that the Notch intracellular domain (NIC), the active form of Notch receptors, activates a reporter driven by the FOXP3 promoter. Dissection of the FOXP3 promoter revealed bipartite effects of the RBP-J-binding site and the N-boxes: the RBP-J-binding site positively, while the N-boxes negatively regulated the FOXP3 promoter activity. Moreover, in freshly isolated Tregs, NIC-RBP-J complex is bound to the FOXP3 promoter in Tregs. Our results suggest that Notch signaling might be involved in the development and function of Tregs through regulating Foxp3 expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.