ArticleNeonatology2009
Characterization and differentiation of iron status in anemic very low birth weight infants using a diagnostic nomogram.
Article in Neonatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Late erythropoiesis-stimulating agents to prevent red blood cell transfusion in preterm or low birth weight infants.The Cochrane database of systematic reviews · 2020Pooled it
- Late erythropoiesis-stimulating agents to prevent red blood cell transfusion in preterm or low birth weight infants.The Cochrane database of systematic reviews · 2019Pooled it
- Effect of High-Dose Erythropoietin on Blood Transfusions in Extremely Low Gestational Age Neonates: Post Hoc Analysis of a Randomized Clinical Trial.JAMA pediatrics · 2020Trial
- Assessment of Urinary Ferritin as a Non-Invasive Diagnostic Test for Iron Deficiency Anemia in Pediatric Populations: A Case-Control Study.Iranian journal of pathology · 2026Article
- 40 years neonatology : An academic life.Wiener klinische Wochenschrift · 2025Review
- Impact and interactions between risk factors on the iron status of at-risk neonates.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Evaluation of the Relationship Between Serum and Urine Ferritin Level of Low Birth Weight Infants.Iranian journal of pathology · 2022Article
- Ferritin in serum and urine: A pilot study.Blood cells, molecules & diseases · 2019Article
- Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults.Journal of clinical laboratory analysis · 2016Article
- Reference intervals for reticulocyte parameters of infants during their first 90 days after birth.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Neonatal iron status is impaired by maternal obesity and excessive weight gain during pregnancy.Journal of perinatology : official journal of the California Perinatal Association · 2014Observational
- A new concept for the differential diagnosis and therapy of anaemia in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIn the early weeks of life, very low birth weight (VLBW) infants experience intense laboratory blood sampling leading to clinically significant anemia and the need for red blood cell transfusion. Although controversial, treatment with recombinant human erythropoietin (EPO) and iron has been recommended to stimulate erythropoiesis; optimal dosing of EPO and iron is still uncertain.
objectivesTo assess the validity of a four-quadrant diagnostic plot of iron availability (ferritin index) versus iron demand for erythropoiesis (reticulocyte hemoglobin content, CHr) for differentiating iron status in anemic VLBW infants.
methodsStudy subjects were enrolled in a previously reported randomized controlled trial of clinically stable VLBW infants <31 weeks' gestation and <1,300 g at birth to receive 18 days of treatment with: group 1: oral iron; group 2: EPO + oral iron, and group 3: EPO + intravenous + oral iron.
resultsAt the end of treatment the ferritin index was significantly higher in both EPO groups compared to the control group. By day 18, CHr of the control group declined into the quadrant of the diagnostic plot characteristic of functional iron deficiency and anemia of chronic disease. Both EPO groups ended in the quadrants that are characteristic for latent iron deficiency and iron deficiency anemia, respectively.
conclusionsThe diagnostic plot for differentiating anemia in VLBW infants may be an informative, clinically useful tool for iron status assessment under different physiologic and therapeutic erythropoietic states. Larger additional studies in difficult patient populations are needed before the clinical utility of this diagnostic procedure can be unequivocally confirmed.
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