ArticleAmerican journal of respiratory and critical care medicine2008
Smoking-related genomic signatures in non-small cell lung cancer.
Article in American journal of respiratory and critical care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Meta-analyses of gene methylation and smoking behavior in non-small cell lung cancer patients.Scientific reports · 2015Pooled it
- Functional Profiling of DNA Repair Pathways in Lung Cancer Patients Uncovers Radiotherapy-Induced and Cancer-Associated Alterations in Oxidative Lesion Repair.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Cigarette smoke and decreased DNA repair by Xeroderma Pigmentosum Group C use a double hit mechanism for epithelial cell lung carcinogenesis.Oncotarget · 2025Article
- Elucidating the role of EPPK1 in lung adenocarcinoma development.BMC cancer · 2024Article
- Telomere Status of Advanced Non-Small-Cell Lung Cancer Offers a Novel Promising Prognostic and Predictive Biomarker.Cancers · 2022Article
- Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts YAP Negative Feedback and Promotes Malignant Progression of Non-small Cell Lung Cancer.International journal of biological sciences · 2022Article
- The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2020Article
- Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer.Cell death & disease · 2017Article
- Identification of an atypical etiological head and neck squamous carcinoma subtype featuring the CpG island methylator phenotype.EBioMedicine · 2017Article
- RNA-seq analysis of lung adenocarcinomas reveals different gene expression profiles between smoking and nonsmoking patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- ASCL1 and RET expression defines a clinically relevant subgroup of lung adenocarcinoma characterized by neuroendocrine differentiation.Oncogene · 2014Article
- The detection and implication of genome instability in cancer.Cancer metastasis reviews · 2013Review
- Accumulation of genomic alterations in 2p16, 9q33.1 and 19p13 in lung tumours of asbestos-exposed patients.Molecular oncology · 2013Article
- A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis.International journal of oncology · 2012Article
- Pathway-based identification of a smoking associated 6-gene signature predictive of lung cancer risk and survival.Artificial intelligence in medicine · 2012Article
- Article
- Cigarette smoking increases copy number alterations in nonsmall-cell lung cancer.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway.Oncogene · 2010Article
- Network-Based Identification of Smoking-Associated Gene Signature for Lung Cancer.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleTobacco smoking is responsible for 85% of all lung cancers. To further our understanding of the molecular pathogenesis of lung cancer, we determined whether smoking history leads to the emergence of specific genomic alterations found in non-small cell lung cancer (NSCLC).
objectivesTo identify gene copy number alterations in NSCLCs associated with smoking history or DNA repair capacity.
methodsSeventy-five NSCLCs were selected for this study from patients with current, none, or past smoking history, including pack year information. Tissue sections were microdissected, and DNA was extracted, purified, and labeled by random priming before hybridization onto bacterial artificial chromosome (BAC) arrays. Normalized ratios were correlated with smoking history and DNA repair capacity was measured by an in vitro lymphocyte assay in the same patients. MEASUREMENTS AND MAIN
resultsWe identified smoking-related genomic signatures in NSCLCs that could be predicted with an overall 74% accuracy. Lung tumors arising from current-smokers had the greatest number of copy number alterations. The genomic regions most significantly associated with smoking were located within 60 regions and were functionally associated with genes controlling the M phase of the cell cycle, the segregation of chromosomes, and the methylation of DNA. Verification of the data is provided from data in the public domain and by quantitative real-time polymerase chain reaction. The associations between genomic abnormalities and DNA repair capacity did not reach statistical significance.
conclusionsThese findings indicate that smoking history leaves a specific genomic signature in the DNA of lung tumors and suggest that these alterations may reflect new molecular pathways to cancer development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.