ArticleEukaryotic cell2008
Structural and functional association of Trypanosoma brucei MIX protein with cytochrome c oxidase complex.
Article in Eukaryotic cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- The mitochondrial proteome of diplonemids: from conventional pathways to eccentric RNA editing and transcript processing.BMC genomics · 2025Article
- Mechanisms of life cycle simplification in African trypanosomes.Nature communications · 2024Article
- Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes.Biological reviews of the Cambridge Philosophical Society · 2023Article
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- The Remarkable Metabolism ofPathogens (Basel, Switzerland) · 2021Article
- Native aggregation is a common feature among triosephosphate isomerases of different species.Scientific reports · 2020Article
- The atypical subunit composition of respiratory complexes I and IV is associated with original extra structural domains in Euglena gracilis.Scientific reports · 2018Article
- Emerging therapeutic targets for treatment of leishmaniasis.Expert opinion on therapeutic targets · 2018Review
- Gene expression to mitochondrial metabolism: Variability among cultured Trypanosoma cruzi strains.PloS one · 2018Article
- A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex.PLoS pathogens · 2017Review
- RNA interference screen reveals a high proportion of mitochondrial proteins essential for correct cell cycle progress in Trypanosoma brucei.BMC genomics · 2015Article
- LACK, a RACK1 ortholog, facilitates cytochrome c oxidase subunit expression to promote Leishmania major fitness.Molecular microbiology · 2015Article
- The ADP/ATP carrier and its relationship to oxidative phosphorylation in ancestral protist trypanosoma brucei.Eukaryotic cell · 2015Article
- Mitochondrial and nucleolar localization of cysteine desulfurase Nfs and the scaffold protein Isu in Trypanosoma brucei.Eukaryotic cell · 2014Article
- Mitochondria and trypanosomatids: targets and drugs.Pharmaceutical research · 2011Review
- Trypanosoma brucei mitochondrial respiratome: composition and organization in procyclic form.Molecular & cellular proteomics : MCP · 2011Article
- Crystal structure of the Leishmania major MIX protein: a scaffold protein that mediates protein-protein interactions.Protein science : a publication of the Protein Society · 2011Article
- Identification and characterization of genes involved in leishmania pathogenesis: the potential for drug target selection.Molecular biology international · 2011Article
- Functional genome annotation by combined analysis across microarray studies of Trypanosoma brucei.PLoS neglected tropical diseases · 2010Article
- Characterization of a Leishmania stage-specific mitochondrial membrane protein that enhances the activity of cytochrome c oxidase and its role in virulence.Molecular microbiology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
A mitochondrial inner membrane protein, designated MIX, seems to be essential for cell viability. The deletion of both alleles was not possible, and the deletion of a single allele led to a loss of virulence and aberrant mitochondrial segregation and cell division in Leishmania major. However, the mechanism by which MIX exerts its effect has not been determined. We show here that MIX is also expressed in the mitochondrion of Trypanosoma brucei, and using RNA interference, we found that its loss leads to a phenotype that is similar to that described for Leishmania. The loss of MIX also had a major effect on cytochrome c oxidase activity, on the mitochondrial membrane potential, and on the production of mitochondrial ATP by oxidative phosphorylation. Using a tandem affinity purification tag, we found that MIX is associated with a multiprotein complex that contains subunits of the mitochondrial cytochrome c oxidase complex (respiratory complex IV), the composition of which was characterized in detail. The specific function of MIX is unknown, but it appears to be important for the function of complex IV and for mitochondrial segregation and cell division in T. brucei.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.