ArticleJournal of bacteriology2008
The chromate-inducible chrBACF operon from the transposable element TnOtChr confers resistance to chromium(VI) and superoxide.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Operonic architecture of bacterial metal response: envelope constraints, evolutionary mobility, and bioremediation design rules.World journal of microbiology & biotechnology · 2026Review
- Understanding the role of vanadium: insights into bacterial responses and adaptations.Frontiers in microbiology · 2026Review
- Microbial Contributions to Heavy Metal Phytoremediation in Agricultural Soils: A Review.Microorganisms · 2024Review
- Landscape of the metaplasmidome of deep-sea hydrothermal vents located at Arctic Mid-Ocean Ridges in the Norwegian-Greenland Sea: ecological insights from comparative analysis of plasmid identification tools.FEMS microbiology ecology · 2024Article
- Novel method of removing metals from estuarine water using whole microbial mats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Unravelling the mechanisms of antibiotic and heavy metal resistance co-selection in environmental bacteria.FEMS microbiology reviews · 2024Review
- Adsorption of HgBMC biotechnology · 2024Article
- ATR activation by Cr-DNA damage is a major survival response establishing late S and G2 checkpoints after Cr(VI) exposure.Toxicology and applied pharmacology · 2023Article
- Chromium contamination accentuates changes in the microbiome and heavy metal resistome of a tropical agricultural soil.World journal of microbiology & biotechnology · 2023Article
- Molecular Characterization of Indigenous Rhizobia from Kenyan Soils Nodulating with Common Beans.International journal of molecular sciences · 2023Article
- A novel gene from the acidophilic bacterium Leptospirillum sp. CF-1 and its role in oxidative stress and chromate tolerance.Biological research · 2022Article
- Implantation ofFrontiers in microbiology · 2022Article
- Transcriptome analysis provides new insights into the tolerance and reduction of Lysinibacillus fusiformis 15-4 to hexavalent chromium.Applied microbiology and biotechnology · 2021Article
- Highly Sensitive Luminescent Bioassay Using RecombinantBiosensors · 2021Article
- Article
- Transcriptome Analysis Reveals Cr(VI) Adaptation Mechanisms inFrontiers in microbiology · 2021Article
- Exploiting the biological response of two Serratia fonticola strains to the critical metals, gallium and indium.Scientific reports · 2020Article
- Removal of Chromium (VI) byJournal of microbiology and biotechnology · 2020Article
- Successive use of microorganisms to remove chromium from wastewater.Applied microbiology and biotechnology · 2020Review
- Heavy Metal Toxicity in Armed Conflicts Potentiates AMR inFrontiers in microbiology · 2020Review
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6 authors.
Funding
Abstract
Large-scale industrial use of chromium(VI) has resulted in widespread contamination with carcinogenic chromium(VI). The abilities of microorganisms to survive in these environments and to detoxify chromate require the presence of specific resistance systems. Here we report identification of the transposon-located (TnOtChr) chromate resistance genes from the highly tolerant strain Ochrobactrum tritici 5bvl1 surviving chromate concentrations of >50 mM. The 7,189-bp-long TnOtChr of the mixed Tn21/Tn3 transposon subfamily contains a group of chrB, chrA, chrC, and chrF genes situated between divergently transcribed resolvase and transposase genes. The chrB and chrA genes, but not chrF or chrC, were essential for establishment of high resistance in chromium-sensitive O. tritici. The chr promoter was strongly induced by chromate or dichromate, but it was completely unresponsive to Cr(III), oxidants, sulfate, or other oxyanions. Plasmid reporter experiments identified ChrB as a chromate-sensing regulator of chr expression. Induction of the chr operon suppressed accumulation of cellular Cr through the activity of a chromate efflux pump encoded by chrA. Expression of chrB, chrC, or chrF in an Escherichia coli sodA sodB double mutant restored its aerobic growth in minimal medium and conferred resistance to superoxide-generating agents menadione and paraquat. Nitroblue tetrazolium staining on native gels showed that ChrC protein had superoxide dismutase activity. TnOtChr appears to represent a mobile genetic system for the distribution of the chromate-regulated resistance operon. The presence of three genes protecting against superoxide toxicity should provide an additional survival advantage to TnOtChr-containing cells in the environments with multiple redox-active contaminants.
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