ArticleThe Journal of biological chemistry2008
Tunable calcium current through TRPV1 receptor channels.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Expression and mechanism of TRPV1 channel in prefrontal cortex after acute hypoxic exercise.BMC sports science, medicine & rehabilitation · 2026Article
- Reduction of the CaFrontiers in cellular neuroscience · 2025Review
- Leveraging the ATP-P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications.Medicinal research reviews · 2023Review
- TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons.eLife · 2022Article
- Inferiority complex: why do sensory ion channels multimerize?Biochemical Society transactions · 2022Review
- Local CaScience signaling · 2020Article
- Direct Anandamide Activation of TRPV1 Produces Divergent Calcium and Current Responses.Frontiers in molecular neuroscience · 2017Article
- Measurement of relative Ca²⁺ permeability during sustained activation of TRPV1 receptors.Pflugers Archiv : European journal of physiology · 2016Article
- ATP-induced P2X Receptor-Dependent Large Pore Formation: How Much Do We Know?Frontiers in pharmacology · 2016Article
- Phosphoinositide regulation of TRPV1 revisited.Pflugers Archiv : European journal of physiology · 2015Review
- Membrane Protein Properties Revealed through Data-Rich Electrostatics Calculations.Structure (London, England : 1993) · 2015Article
- Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides.Science signaling · 2015Article
- Glucose concentration in culture medium affects mRNA expression of TRPV1 and CB1 receptors and changes capsaicin toxicity in PC12 cells.Iranian journal of basic medical sciences · 2014Article
- Principles and properties of ion flow in P2X receptors.Frontiers in cellular neuroscience · 2014Review
- Allosteric modulation of Ca2+ flux in ligand-gated cation channel (P2X4) by actions on lateral portals.The Journal of biological chemistry · 2012Article
- TRPV1: a stress response protein in the central nervous system.American journal of neurodegenerative disease · 2012Article
- Calcium-dependent decrease in the single-channel conductance of TRPV1.Pflugers Archiv : European journal of physiology · 2011Article
- Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Properties of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation.The Journal of biological chemistry · 2010Article
- Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1.Biophysical journal · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TRPV1 receptors are polymodal cation channels that open in response to diverse stimuli including noxious heat, capsaicin, and protons. Because Ca2+ is vital for TRPV1 signaling, we sought to precisely measure its contribution to TRPV1 responses and discovered that the Ca2+ current was tuned by the mode of activation. Using patch clamp photometry, we found that the fraction of the total current carried by Ca2+ (called the Pf%) was significantly smaller for TRPV1 currents evoked by protons than for those evoked by capsaicin. Using site-directed mutagenesis, we discovered that the smaller Pf% was due to protonation of three acidic amino acids (Asp646, Glu648, and Glu651) that are located in the mouth of the pore. Thus, in keeping with recent reports of time-dependent changes in the ionic permeability of some ligand-gated ion channels, we now show for the first time that the physiologically important Ca2+ current of the TRPV1 receptor is also dynamic and depends on the mode of activation. This current is significantly smaller when the receptor is activated by a change in pH, owing to atomic scale interactions of H+ and Ca2+ with the fixed negative charge of side chains in the pore.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.