ArticlePlant physiology2008
AtCCX3 is an Arabidopsis endomembrane H+ -dependent K+ transporter.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
- Evolutionary dynamics of the calcium/cation antiporter superfamily in Brassicaceae: codon usage, selection pressure, andFrontiers in plant science · 2025Article
- Comparative Analysis of CaPlants (Basel, Switzerland) · 2024Article
- Golgi apparatus-localized CATION CALCIUM EXCHANGER4 promotes osmotolerance of Arabidopsis.Plant physiology · 2024Article
- Genome-Wide Identification ofGenes · 2023Article
- Structure, Function, and Applications of Soybean Calcium Transporters.International journal of molecular sciences · 2022Review
- Calcium channels and transporters: Roles in response to biotic and abiotic stresses.Frontiers in plant science · 2022Review
- Delineating Calcium Signaling Machinery in Plants: Tapping the Potential through Functional Genomics.Current genomics · 2021Review
- The CaCA superfamily genes in Saccharum: comparative analysis and their functional implications in response to biotic and abiotic stress.BMC genomics · 2021Article
- Phylogenetic and ion-response analyses reveal a relationship between gene expansion and functional divergence in the CaPlant molecular biology · 2021Article
- Cation/CaFrontiers in plant science · 2021Article
- Identification and Expression Profiling Analysis of the Cation/CaFrontiers in genetics · 2021Article
- Plant Soft Rot Development and Regulation from the Viewpoint of Transcriptomic Profiling.Plants (Basel, Switzerland) · 2020Article
- Suppression of class I compensated cell enlargement by xs2 mutation is mediated by salicylic acid signaling.PLoS genetics · 2020Article
- Manganese in Plants: From Acquisition to Subcellular Allocation.Frontiers in plant science · 2020Review
- Chloroplast Calcium Signaling in the Spotlight.Frontiers in plant science · 2020Review
- Characterization and Expression Analysis of the CaPlants (Basel, Switzerland) · 2019Article
- Article
- Endoplasmic reticulum-localized CCX2 is required for osmotolerance by regulating ER and cytosolic CaProceedings of the National Academy of Sciences of the United States of America · 2018Article
- A Node-Expressed Transporter OsCCX2 Is Involved in Grain Cadmium Accumulation of Rice.Frontiers in plant science · 2018Article
- Salt stress-induced FERROCHELATASE 1 improves resistance to salt stress by limiting sodium accumulation in Arabidopsis thaliana.Scientific reports · 2017Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arabidopsis (Arabidopsis thaliana) cation calcium exchangers (CCXs) were recently identified as a subfamily of cation transporters; however, no plant CCXs have been functionally characterized. Here, we show that Arabidopsis AtCCX3 (At3g14070) and AtCCX4 (At1g54115) can suppress yeast mutants defective in Na(+), K(+), and Mn(2+) transport. We also report high-capacity uptake of (86)Rb(+) in tonoplast-enriched vesicles from yeast expressing AtCCX3. Cation competition studies showed inhibition of (86)Rb(+) uptake in AtCCX3 cells by excess Na(+), K(+), and Mn(2+). Functional epitope-tagged AtCCX3 fusion proteins were localized to endomembranes in plants and yeast. In Arabidopsis, AtCCX3 is primarily expressed in flowers, while AtCCX4 is expressed throughout the plant. Quantitative polymerase chain reaction showed that expression of AtCCX3 increased in plants treated with NaCl, KCl, and MnCl(2). Insertional mutant lines of AtCCX3 and AtCCX4 displayed no apparent growth defects; however, overexpression of AtCCX3 caused increased Na(+) accumulation and increased (86)Rb(+) transport. Uptake of (86)Rb(+) increased in tonoplast-enriched membranes isolated from Arabidopsis lines expressing CCX3 driven by the cauliflower mosaic virus 35S promoter. Overexpression of AtCCX3 in tobacco (Nicotiana tabacum) produced lesions in the leaves, stunted growth, and resulted in the accumulation of higher levels of numerous cations. In summary, these findings suggest that AtCCX3 is an endomembrane-localized H(+)-dependent K(+) transporter with apparent Na(+) and Mn(2+) transport properties distinct from those of previously characterized plant transporters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.