ArticleThe Journal of experimental biology2008
Fish and chips: functional genomics of social plasticity in an African cichlid fish.
Article in The Journal of experimental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dissecting the Transcriptional Patterns of Social Dominance across Teleosts.Integrative and comparative biology · 2016Pooled it
- Single-Nucleus Transcriptomics of the Mouse Medial Preoptic Area Reveals Sex-Dependent Molecular Signatures of Social Dominance.bioRxiv : the preprint server for biology · 2026Article
- Genomic and neurobiological bases of variation in fighting strategies in gamecocks.Molecular biology and evolution · 2026Article
- Adult sex change leads to extensive forebrain reorganization in clownfish.Biology of sex differences · 2024Article
- A perspective on neuroethology: what the past teaches us about the future of neuroethology.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Adult sex change leads to extensive forebrain reorganization in clownfish.bioRxiv : the preprint server for biology · 2024Article
- Molecular, behavioural and morphological comparisons of sperm adaptations in a fish with alternative reproductive tactics.Evolutionary applications · 2023Article
- Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Transcriptomes of testis and pituitary from male Nile tilapia (O. niloticus L.) in the context of social status.PloS one · 2022Article
- Social boldness correlates with brain gene expression in male green anoles.Hormones and behavior · 2021Article
- Prenatal testosterone triggers long-term behavioral changes in male zebra finches: unravelling the neurogenomic mechanisms.BMC genomics · 2021Article
- Neuroendocrine Mechanisms Underlying Non-breeding Aggression: Common Strategies Between Birds and Fish.Frontiers in neural circuits · 2021Review
- Vocal and Electric Fish: Revisiting a Comparison of Two Teleost Models in the Neuroethology of Social Behavior.Frontiers in neural circuits · 2021Review
- Sexual Dimorphism in Aggression: Sex-Specific Fighting Strategies Across Species.Frontiers in behavioral neuroscience · 2021Review
- Behavior-related gene regulatory networks: A new level of organization in the brain.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Article
- How research on female vertebrates contributes to an expanded challenge hypothesis.Hormones and behavior · 2020Review
- Brain transcriptomics of agonistic behaviour in the weakly electric fish Gymnotus omarorum, a wild teleost model of non-breeding aggression.Scientific reports · 2020Article
- Behavioral and brain- transcriptomic synchronization between the two opponents of a fighting pair of the fish Betta splendens.PLoS genetics · 2020Article
- Galanin immunoreactivity is sexually polymorphic in neuroendocrine and vocal-acoustic systems in a teleost fish.The Journal of comparative neurology · 2020Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
Behavior and physiology are regulated by both environment and social context. A central goal in the study of the social control of behavior is to determine the underlying physiological, cellular and molecular mechanisms in the brain. The African cichlid fish Astatotilapia burtoni has long been used as a model system to study how social interactions regulate neural and behavioral plasticity. In this species, males are either socially dominant and reproductively active or subordinate and reproductively suppressed. This phenotypic difference is reversible. Using an integrative approach that combines quantitative behavioral measurements, functional genomics and bioinformatic analyses, we examine neural gene expression in dominant and subordinate males as well as in brooding females. We confirm the role of numerous candidate genes that are part of neuroendocrine pathways and show that specific co-regulated gene sets (modules), as well as specific functional gene ontology categories, are significantly associated with either dominance or reproductive state. Finally, even though the dominant and subordinate phenotypes are robustly defined, we find a surprisingly high degree of individual variation in the transcript levels of the very genes that are differentially regulated between these phenotypes. The results of the present study demonstrate the molecular complexity in the brain underlying social behavior, identify novel targets for future studies, validate many candidate genes and exploit individual variation in order to gain biological insights.
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