Evidence map›Paper›PMID 18775794›Full record

ReviewCurrent opinion in chemical biology2008

Artificial beta-sheets: chemical models of beta-sheets.

Omid Khakshoor, James S Nowick

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Dissecting the Conformational Stability of a Glycan Hairpin.Journal of the American Chemical Society · 2024
    Article
  3. Macrocyclic β-Sheets Stabilized by Hydrogen Bond Surrogates.Angewandte Chemie (International ed. in English) · 2023
    Article
  4. Synthesis of a glycan hairpin.Nature chemistry · 2023
    Article
  5. Article
  6. An Improved Turn Structure for Inducing β-Hairpin Formation in Peptides.Angewandte Chemie (International ed. in English) · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The supramolecular chemistry of β-sheets.Journal of the American Chemical Society · 2013
    Review
  12. Computational design of a symmetric homodimer using β-strand assembly.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
  13. Giant macrolactams based on β-sheet peptides.The Journal of organic chemistry · 2011
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Omid KhakshoorDepartment of Chemistry, University of California, Irvine, Irvine, CA 92697-2025, USA.
James S Nowick

Funding

CHEMICAL MODELS OF PROTEIN BETA SHEET INTERACTIONSR01GM049076 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 1999 to 2009
$1.7M
NEW STRATEGIES FOR FORMATION OF PEPTIDE BETA-SHEETSR29GM049076 · NIGMS · UNIVERSITY OF CALIFORNIA IRVINE · PI NOWICK, JAMES S · 1994 to 1998
–
NIGMS NIH HHS GM-49076NIGMS NIH HHS R01 GM049076
6 · The paper itself

Abstract

Chemical models provide tools with which to simplify and study complicated biological systems. Forces and chemical processes that govern the structure, function, and interactions of a biomacromolecule can be explored with a simple, easy-to-study synthetic molecule. Chemical models of beta-sheet structures have helped to elucidate the factors influencing protein structures and functions. Chemical models that mimic beta-sheet quaternary structure and interactions are emerging as valuable tools with which to better understand and control protein recognition and protein aggregation.

Indexed as

Models, ChemicalBiomimetic MaterialsHumansPeptides, CyclicProteinsProtein Structure, SecondaryPeptides, CyclicProteins

Identifiers

PMID18775794
PMCPMC2646360

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.