ArticleMolecular and biochemical parasitology2008
Microarray based analysis of temperature and oxidative stress induced messenger RNA in Schistosoma mansoni.
Article in Molecular and biochemical parasitology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Oxidative Stress and Cancer Risk in Schistosomiasis.Oxidative medicine and cellular longevity · 2024Review
- Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: Hepatoprotective and enhancer of etiological treatment.PLoS neglected tropical diseases · 2021Article
- Heat shock protein 70 (Hsp70) inParasitology · 2020Review
- Targeting Kinases inFrontiers in veterinary science · 2020Article
- Article
- Universal Stress Proteins as New Targets for Environmental and Therapeutic Interventions of Schistosomiasis.International journal of environmental research and public health · 2016Review
- Article
- Proteasome stress responses in Schistosoma mansoni.Parasitology research · 2015Article
- Imatinib treatment causes substantial transcriptional changes in adult Schistosoma mansoni in vitro exhibiting pleiotropic effects.PLoS neglected tropical diseases · 2014Article
- Development of "-omics" research in Schistosoma spp. and -omics-based new diagnostic tools for schistosomiasis.Frontiers in microbiology · 2014Review
- Proteomic and systems biology analysis of the monocyte response to Coxiella burnetii infection.PloS one · 2013Article
- Inferences on the biochemical and environmental regulation of universal stress proteins from Schistosomiasis parasites.Advances and applications in bioinformatics and chemistry : AABC · 2013Article
- Gender-associated genes in filarial nematodes are important for reproduction and potential intervention targets.PLoS neglected tropical diseases · 2011Article
- Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni.Gene regulation and systems biology · 2011Article
- Transcriptional changes in Schistosoma mansoni during early schistosomula development and in the presence of erythrocytes.PLoS neglected tropical diseases · 2010Article
- Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment.PLoS neglected tropical diseases · 2009Article
- Towards an understanding of the mechanism of action of praziquantel.Molecular and biochemical parasitology · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The body's defense against schistosome infection can take many forms. For example, upon developing acute schistosomiasis, patients often have fever coinciding with larval maturation, migration and early oviposition. As the infection becomes established, the parasite comes under oxidative stress generated by the host immune system. The most common treatment for schistosomiasis is the anti-helminthic drug praziquantel. Its effectiveness, however, is limited due to its inability to kill schistosomes 2-4 weeks post-infection. Clearly there is a need for new anti-schistosomal drugs. We hypothesize that gene products expressed as part of a protective response against heat and/or oxidative stress are potential therapeutic targets for future drug development. Using a 12,166 element oligonucleotide microarray to characterize Schistosoma mansoni genes induced by heat and oxidative stress we found that 1878 S. mansoni elements were significantly induced by heat stress. These included previously reported heat-shock genes expressing homologs of HSP40, HSP70 and HSP86. One thousand and one elements were induced by oxidative stress including those expressing homologs of superoxide dismutase, glutathione peroxidase and aldehyde dehydrogenase. Seventy-two elements were common to both stressors and could potentially be exploited in the development of novel anti-schistosomal therapeutics.
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Registered trials
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