ArticleCancer science2008
Characteristics and modifying factors of asbestos-induced oxidative DNA damage.
Article in Cancer science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 77 citations in OpenAlex.
- Evaluation of respiratory toxicity and peritoneal mesothelioma induced by heat-treated and milled amosite following intratracheal and intraperitoneal injection in rats.Industrial health · 2026Article
- Mesothelioma carcinogenesis of chrysotile and forsterite compared and validated by intraperitoneal injection in rat.Industrial health · 2025Article
- Comparison of various methodological approaches to model asbestos thresholds for mesothelioma.Frontiers in public health · 2025Review
- Effect of Synthetic Vitreous Fiber Exposure on TMEM16A Channels in aInternational journal of molecular sciences · 2024Article
- BRCA1 haploinsufficiency impairs iron metabolism to promote chrysotile-induced mesothelioma via ferroptosis resistance.Cancer science · 2023Article
- Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?Nanomaterials (Basel, Switzerland) · 2022Review
- Prognosis of resected non-small cell lung cancer with pleural plaques on intrathoracic findings.BMC cancer · 2022Article
- Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin.Redox biology · 2021Article
- Asbestos-induced chronic inflammation in malignant pleural mesothelioma and related therapeutic approaches-a narrative review.Precision cancer medicine · 2021Article
- Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium.Redox biology · 2020Article
- Lung injury and expression of p53 and p16 in Wistar rats induced by respirable chrysotile fiber dust from four primary areas of China.Environmental science and pollution research international · 2018Article
- In vitro genotoxicity of asbestos substitutes induced by coupled stimulation of dissolved high-valence ions and oxide radicals.Environmental science and pollution research international · 2018Article
- Receptor role of the annexin A2 in the mesothelial endocytosis of crocidolite fibers.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Asbestos and multi-walled carbon nanotubes generate distinct oxidative responses in inflammatory cells.Journal of clinical biochemistry and nutrition · 2015Article
- Concurrent occurrence of renal cell carcinoma with rhabdoid features in a married couple: a case report.BMC research notes · 2015Article
- DNA dynamics during early double-strand break processing revealed by non-intrusive imaging of living cells.PLoS genetics · 2014Article
- Rat model demonstrates a high risk of tremolite but a low risk of anthophyllite for mesothelial carcinogenesis.Nagoya journal of medical science · 2014Article
- Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis.Redox report : communications in free radical research · 2014Review
- Evaluation of two distinct methods to quantify the uptake of crocidolite fibers by mesothelial cells.Journal of clinical biochemistry and nutrition · 2013Article
- Distinct affinity of nuclear proteins to the surface of chrysotile and crocidolite.Journal of clinical biochemistry and nutrition · 2012Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory exposure to asbestos has been linked with mesothelioma in humans. However, its carcinogenic mechanism is still unclear. Here we studied the ability of chrysotile, crocidolite and amosite fibers to induce oxidative DNA damage and the modifying factors using four distinct approaches. Electron spin resonance analyses revealed that crocidolite and amosite containing high amounts of iron, but not chrysotile, catalyzed hydroxyl radical generation in the presence of H(2)O(2), which was enhanced by an iron chelator, nitrilotriacetic acid, and suppressed by desferal. Natural iron chelators, such as citrate, adenosine 5'-triphosphate and guanosine 5'-triphosphate, did not inhibit this reaction. Second, we used time-lapse video microscopy to evaluate how cells cope with asbestos fibers. RAW264.7 cells, MeT-5 A and HeLa cells engulfed asbestos fibers, which reached not only cytoplasm but also the nucleus. Third, we utilized supercoiled plasmid DNA to evaluate the ability of each asbestos to induce DNA double strand breaks (DSB). Crocidolite and amosite, but not chrysotile, induced DNA DSB in the presence of iron chelators. We cloned the fragments to identify break sites. DSB occurred preferentially within repeat sequences and between two G:C sequences. Finally, i.p. administration of each asbestos to rats induced not only formation of nuclear 8-hydroxy-2'-deoxyguanosine in the mesothelia, spleen, liver and kidney but also significant iron deposits in the spleen. Together with the established carcinogenicity of i.p. chrysotile, our data suggest that asbestos-associated catalytic iron, whether constitutional or induced by other mechanisms, plays an important role in asbestos-induced carcinogenesis and that chemoprevention may be possible through targeting the catalytic iron.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.