Evidence map›Paper›PMID 18774186›Full record

ArticleTrends in neurosciences2008

Targeting TNF-alpha receptors for neurotherapeutics.

Wayne Chadwick, Tim Magnus, Bronwen Martin, Aleksander Keselman, Mark P Mattson, Stuart Maudsley

Abstract read
In one paragraph

Article in Trends in neurosciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Secondary Mania induced by TNF-α inhibitors: A systematic review.Psychiatry and clinical neurosciences · 2022
    Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. System level modeling and analysis of TNF-Frontiers in physiology · 2022
    Article
  17. Decoding Mast Cell-Microglia Communication in Neurodegenerative Diseases.International journal of molecular sciences · 2021
    Review
  18. Injury-Induced Effectors of Neuropathic Pain.Molecular neurobiology · 2020
    Review
  19. Article
  20. G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence.Computational and structural biotechnology journal · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wayne ChadwickReceptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
Tim Magnus
Bronwen Martin
Aleksander Keselman
Mark P Mattson
Stuart Maudsley

Funding

Apoptosis In Neurodegenerative DisordersZIAAG000313 · NIA · NATIONAL INSTITUTE ON AGING · PI MATTSON, MARK · 2009 to 2018
$6.4M
Neuro-Immune Mechanisms in Brain Plasticity and AgingZIAAG000332 · NIA · NATIONAL INSTITUTE ON AGING · PI MATTSON, MARK · 2009 to 2018
$4.2M
Innate intelligence and prognostication for prevention of neurodegenerationZIAAG000319 · NIA · NATIONAL INSTITUTE ON AGING · PI MAUDSLEY, STUART · 2009 to 2012
$1.0M
Age and pathology-induced alteration of G protein-coupled receptor signalingZ01AG000318 · NIA · NATIONAL INSTITUTE ON AGING · PI MAUDSLEY, STUART · 2007 to 2008
$905k
Intramural NIH HHS Z01 AG000318
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsHumansModels, BiologicalNervous System DiseasesReceptors, Tumor Necrosis FactorSignal TransductionTumor Necrosis Factor-alphaReceptors, Tumor Necrosis FactorTumor Necrosis Factor-alpha

Identifiers

PMID18774186
PMCPMC2574933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.