ReviewTrends in pharmacological sciences2008
Multivariate analyses reveal common and drug-specific genetic influences on responses to four drugs of abuse.
Review in Trends in pharmacological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Discovery and validation of genes driving drug-intake and related behavioral traits in mice.Genes, brain, and behavior · 2024Article
- DISCOVERY AND VALIDATION OF GENES DRIVING DRUG-INTAKE AND RELATED BEHAVIORAL TRAITS IN MICE.bioRxiv : the preprint server for biology · 2023Article
- Apremilast Alters Behavioral Responses to Ethanol in Mice: II. Increased Sedation, Intoxication, and Reduced Acute Functional Tolerance.Alcoholism, clinical and experimental research · 2018Article
- Addictions Neuroclinical Assessment: A reverse translational approach.Neuropharmacology · 2017Review
- PPAR Agonists: II. Fenofibrate and Tesaglitazar Alter Behaviors Related to Voluntary Alcohol Consumption.Alcoholism, clinical and experimental research · 2016Article
- Commonalities and Distinctions Among Mechanisms of Addiction to Alcohol and Other Drugs.Alcoholism, clinical and experimental research · 2015Review
- Ethanol tolerance and withdrawal severity in high drinking in the dark selectively bred mice.Alcoholism, clinical and experimental research · 2012Article
- Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
- Behavioral actions of alcohol: phenotypic relations from multivariate analysis of mutant mouse data.Genes, brain, and behavior · 2012Article
- Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark.Alcohol (Fayetteville, N.Y.) · 2011Article
- Operant sensation seeking in the mouse.Journal of visualized experiments : JoVE · 2010Article
- The complexity of alcohol drinking: studies in rodent genetic models.Behavior genetics · 2010Review
- Withdrawal severity after chronic intermittent ethanol in inbred mouse strains.Alcoholism, clinical and experimental research · 2010Article
- A line of mice selected for high blood ethanol concentrations shows drinking in the dark to intoxication.Biological psychiatry · 2009Article
- Genetic correlates of morphine withdrawal in 14 inbred mouse strains.Drug and alcohol dependence · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vulnerability to abused drugs is influenced by multiple genes unique to each drug and to risk genes for polydrug abuse. If several inbred mouse strains respond to different drugs similarly, this implies the action of a common group of genes. Simultaneous analysis of multiple responses to multiple drugs has been attempted infrequently. We performed multivariate analyses of published strain responses to four drugs. Genetic similarity in responses did not simply track pharmacological class. Withdrawal severity and preference for ethanol and diazepam were affected by many genes in common, although inversely. We focused on behavioral responses, but there is a growing archival database of physiological, pharmacological and biochemical strain traits. The genomics community is increasingly focusing on single-nucleotide polymorphism and haplotype-based gene mapping approaches, for which inbred strain data are also useful. Thus, similar analyses should be applicable to other laboratories, traits and genotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.