ArticleExperimental cell research2008
Focal adhesion kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho.
Article in Experimental cell research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Comprehensive study of imidazole-based hydrazones: From design, synthesis, and characterization to in vitro and in silico antiproliferative activity analysis.Turkish journal of chemistry · 2025Article
- CAR Co-Operates With Integrins to Promote Lung Cancer Cell Adhesion and Invasion.Frontiers in oncology · 2022Article
- Suppression of TGF-β1 signaling by Matrigel via FAK signaling in cultured human trabecular meshwork cells.Scientific reports · 2021Article
- The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds.NPJ Regenerative medicine · 2021Article
- Neutrophil-Derived Reactive Oxygen Orchestrates Epithelial Cell Signaling Events during Intestinal Repair.The American journal of pathology · 2019Article
- E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity.Biology open · 2019Article
- Culture Model for Non-human Primate Choroid Plexus.Frontiers in cellular neuroscience · 2019Article
- SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer.Cancer research · 2017Article
- Improvement of paracellular transport in the Caco-2 drug screening model using protein-engineered substrates.Biomaterials · 2017Article
- Integrin beta8 (ITGB8) activates VAV-RAC1 signaling via FAK in the acquisition of endometrial epithelial cell receptivity for blastocyst implantation.Scientific reports · 2017Article
- Multiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion.Cell systems · 2017Article
- Modeling, signaling and cytoskeleton dynamics: integrated modeling-experimental frameworks in cell migration.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- A Computational Model of YAP/TAZ Mechanosensing.Biophysical journal · 2016Article
- PAR-6, but not E-cadherin and β-integrin, is necessary for epithelial polarization in C. elegans.Developmental biology · 2015Article
- The effects of focal adhesion kinase on the motility, proliferation and apoptosis of Caco2 and SMMC-7721 cells.Medical oncology (Northwood, London, England) · 2015Article
- FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.Developmental biology · 2014Article
- SRChing for the substrates of Src.Oncogene · 2014Review
- Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models.Breast cancer research : BCR · 2014Article
- Cyclin-dependent kinase 5 promotes the stability of corneal epithelial cell junctions.Molecular vision · 2013Article
- VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost.Journal of cellular physiology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase that plays a key role in cellular processes such as cell adhesion, migration, proliferation and survival. Recent studies have also implicated FAK in the regulation of cell-cell adhesion. Here, evidence is presented showing that siRNA-mediated suppression of FAK levels in NBT-II cells and expression of dominant negative mutants of FAK caused loss of epithelial cell morphology and inhibited the formation of cell-cell adhesions. Rac and Rho have been implicated in the regulation of cell-cell adhesions and can be regulated by FAK signaling. Expression of active Rac or Rho in NBT-II cells disrupted formation of cell-cell contacts, thus promoting a phenotype similar to FAK-depleted cells. The loss of intercellular contacts in FAK-depleted cells is prevented upon expression of a dominant negative Rho mutant, but not a dominant negative Rac mutant. Inhibition of FAK decreased tyrosine phosphorylation of p190RhoGAP and elevated the level of GTP-bound Rho. This suggests that FAK regulates cell-cell contact formation by regulation of Rho.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.