ArticleDevelopmental biology2008
Maternal Groucho and bHLH repressors amplify the dose-sensitive X chromosome signal in Drosophila sex determination.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- High-affinity biomolecular interactions are modulated by low-affinity binders.NPJ systems biology and applications · 2024Article
- In Vitro Comparison of Sex-Specific Splicing Efficiencies ofJournal of developmental biology · 2023Article
- Transcriptome analysis of sex-biased gene expression in the spotted-wing Drosophila, Drosophila suzukii (Matsumura).G3 (Bethesda, Md.) · 2022Article
- Evidence That Runt Acts as a Counter-Repressor of Groucho DuringG3 (Bethesda, Md.) · 2020Article
- Transcriptome Analysis of the Oriental Fruit FlyInsects · 2020Article
- Article
- Insect Transcription Factors: A Landscape of Their Structures and Biological Functions inInternational journal of molecular sciences · 2018Review
- HLH-29 regulates ovulation in C. elegans by targeting genes in the inositol triphosphate signaling pathway.Biology open · 2012Article
- Cooperative and antagonistic contributions of two heterochromatin proteins to transcriptional regulation of the Drosophila sex determination decision.PLoS genetics · 2011Article
- The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis.Development (Cambridge, England) · 2011Article
- The Drosophila Myc gene, diminutive, is a positive regulator of the Sex-lethal establishment promoter, Sxl-Pe.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Sex and the single embryo: early deveiopment in the Mediterranean fruit fly, Ceratitis capitata.BMC developmental biology · 2010Article
- A shared enhancer controls a temporal switch between promoters during Drosophila primary sex determination.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In Drosophila, XX embryos are fated to develop as females, and XY embryos as males, because the diplo-X dose of four X-linked signal element genes, XSEs, activates the Sex-lethal establishment promoter, SxlPe, whereas the haplo-X XSE dose leaves SxlPe off. The threshold response of SxlPe to XSE concentrations depends in part on the bHLH repressor, Deadpan, present in equal amounts in XX and XY embryos. We identified canonical and non-canonical DNA-binding sites for Dpn at SxlPe and found that cis-acting mutations in the Dpn-binding sites caused stronger and earlier Sxl expression than did deletion of dpn implicating other bHLH repressors in Sxl regulation. Maternal Hey encodes one such bHLH regulator but the E(spl) locus does not. Elimination of the maternal corepressor Groucho also caused strong ectopic Sxl expression in XY, and premature Sxl activation in XX embryos, but Sxl was still expressed differently in the sexes. Our findings suggest that Groucho and associated maternal and zygotic bHLH repressors define the threshold XSE concentrations needed to activate SxlPe and that they participate directly in sex signal amplification. We present a model in which the XSE signal is amplified by a feedback mechanism that interferes with Gro-mediated repression in XX, but not XY embryos.
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