Evidence map›Paper›PMID 18773413›Full record

ReviewJournal of cellular biochemistry2008

Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer.

Mu-Shui Dai, Hua Lu

Open access · greenAbstract readReview
In one paragraph

Review in Journal of cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 155 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Elucidating the Role ofCurrent issues in molecular biology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The Interplay Between theInternational journal of molecular sciences · 2024
    Review
  11. Article
  12. RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Role of c-Myc in lung cancer: Progress, challenges, and prospects.Chinese medical journal pulmonary and critical care medicine · 2023
    Article
  14. MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
  16. Ribosomal Profiling by Gradient Fractionation of Cell Lysates.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  17. Article
  18. Article
  19. KrasGenome biology · 2021
    Article
  20. Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mu-Shui DaiDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine and Simon Cancer Center, Indianapolis, Indiana 46202, USA.
Hua Lu
Indiana University Health · US

Funding

The Role of Ribosomal Proteins in the P53-MDM2 PathwayR01CA095441 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI LU, HUA · 2002 to 2021
$5.1M
Role of ribosomal proteins in regulating c-MycR01CA129828 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI LU, HUA · 2008 to 2012
$1.5M
Study of a FACTp140-SSRP1-associated p53 KinaseR01CA093614 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LU, HUA · 2002 to 2006
$1.5M
Dissection of the feedback inhibition of c-Myc by L11R00CA127134 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAI, MU-SHUI · 2009 to 2011
$740k
Dissection of the feedback inhibition of c-Myc by L11K99CA127134 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAI, MU-SHUI · 2007 to 2008
$186k
NCI NIH HHS CA095441NCI NIH HHS CA 129828NCI NIH HHS CA93614NCI NIH HHS K99 CA127134NCI NIH HHS K99-CA127134NCI NIH HHS R00 CA127134NCI NIH HHS R01 CA093614NCI NIH HHS R01 CA095441NCI NIH HHS R01 CA129828
6 · The paper itself

Abstract

Protein production is driven by protein translation and relies on ribosomal biogenesis, globally essential for cell growth, proliferation, and animal development. Deregulation of these sophisticated cellular processes leads to abnormal homeostasis and carcinogenesis. Thus, their tight regulation is vitally important for a cell to warrant normal growth and proliferation. One newly identified key regulator for ribosomal biogenesis and translation is the oncoprotein c-Myc, whose aberrantly excessive level and activity are highly associated with human cancers, too. Recently, we have shown that ribosomal protein L11 functions as a feedback regulator of c-Myc. Hence, in this review, we will provide some prospects on the interplay between c-Myc and ribosomal proteins during ribosomal biogenesis and discuss its implications in cancer.

Indexed as

AnimalsCell CycleHumansModels, BiologicalNeoplasmsProtein BiosynthesisProto-Oncogene Proteins c-mycRibosomal ProteinsRibosomesProto-Oncogene Proteins c-mycribosomal protein L11Ribosomal Proteins

Identifiers

PMID18773413
PMCPMC2569974
OpenAlexW2087122127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.