ArticlePloS one2008
IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus.Arthritis and rheumatism · 2010Pooled it
- IL-21 boosts T cell-therapy efficacy for solid tumors by enhancing mitochondrial Ca2+-mediated motility of effector CD8+ T cells.Cancer immunology research · 2026Article
- Article
- Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity.International journal of molecular sciences · 2021Review
- IL-21 regulates SOCS1 expression in autoreactive CD8Scientific reports · 2019Article
- The Effects of an IL-21 Receptor Antagonist on the Alloimmune Response in a Humanized Mouse Skin Transplant Model.Transplantation · 2019Article
- IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis.The Journal of clinical investigation · 2015Article
- Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity.The Journal of clinical investigation · 2015Review
- Article
- The PTPN22 1858T allele but not variants in the proximal promoter region of IL-21 gene is associated with the susceptibility to type 1 diabetes and the presence of autoantibodies in a Brazilian cohort.Clinical and experimental immunology · 2013Article
- Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets.Immunity · 2012Article
- Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.The Journal of clinical investigation · 2011Article
- Mapping quantitative trait loci for T lymphocyte subpopulations in peripheral blood in swine.BMC genetics · 2011Article
- Article
- Post-operative infection and sepsis in humans is associated with deficient gene expression of γc cytokines and their apoptosis mediators.Critical care (London, England) · 2011Article
- Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.European journal of immunology · 2011Article
- Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.Diabetes · 2011Article
- Cytokines and type 1 diabetes: a numbers game.Diabetes · 2011Article
- Aberrant ROCK activation promotes the development of type I diabetes in NOD mice.Cellular immunology · 2011Article
- An update on the use of NOD mice to study autoimmune (Type 1) diabetes.Expert review of clinical immunology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIL-21, a member of the common gamma-chain utilizing family of cytokines, participates in immune and inflammatory processes. In addition, the cytokine has been linked to autoimmunity in humans and rodents. METHODOLOGY/PRINCIPAL
findingsTo investigate the mechanism whereby IL-21 affects the immune system, we investigated its role in T cell homeostasis and autoimmunity in both non-autoimmune C57BL/6 and autoimmune NOD mice. Our data indicate that IL-21R knockout C57BL/6 and NOD mice show increased size of their lymphocyte population and decreased homeostatic proliferation. In addition, our experimental results demonstrate that IL-21 inhibits T cell survival. These data suggest that IL-21 acts to limit the size of the T cell pool. Furthermore, our data suggest IL-21 may contribute to the development of autoimmunity. CONCLUSIONS/SIGNIFICANCE: Taken together, our results suggest that IL-21 plays a global role in regulating T cell homeostasis, promoting the continuous adaptation of the T cell lymphoid space.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.