ArticleProceedings of the National Academy of Sciences of the United States of America2008
Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 221 papers.
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Who cites it
221 citing papers in PubMed.
- Temperature as a Regulator of Red Blood Cell Fate: From Membrane Dynamics to Cellular Clearance.Medical sciences (Basel, Switzerland) · 2026Review
- Microfluidic platform for automatic quantification of malaria parasite invasion under physiological flow conditions.Lab on a chip · 2026Article
- Machine learning assisted malaria detection using photonic crystal fibre optical sensors.Scientific reports · 2026Article
- Pathophysiological Associations and Measurement Techniques of Red Blood Cell Deformability.Biosensors · 2025Review
- Isolation Techniques of Micro/Nano-Scaled Species for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- OAH-Net: a deep neural network for efficient and robust hologram reconstruction for off-axis digital holographic microscopy.Biomedical optics express · 2025Article
- Vibrational signatures of living cells.Biophysical journal · 2025Article
- Biomechanics of phagocytosis of red blood cells by macrophages in the human spleen.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Label-Free Optical Transmission Tomography for Direct Mycological Examination and Monitoring of Intracellular Dynamics.Journal of fungi (Basel, Switzerland) · 2024Article
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- Quantitative phase imaging based on holography: trends and new perspectives.Light, science & applications · 2024Review
- Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part I.Journal of biomedical optics · 2024Review
- Imaging the intracellular refractive index distribution (IRID) for dynamic label-free living colon cancer cells via circularly depolarization decay model (CDDM).Biomedical optics express · 2024Article
- Deep learning-assisted smartphone-based quantitative microscopy for label-free peripheral blood smear analysis.Biomedical optics express · 2024Article
- Non-steady state thermometry with optical diffraction tomography.Science advances · 2024Article
- Real-time simultaneous refractive index and thickness mapping of sub-cellular biology at the diffraction limit.Communications biology · 2024Article
- Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells.Biosensors · 2023Article
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- Label-Free Digital Holotomography Reveals Ibuprofen-Induced Morphological Changes to Red Blood Cells.ACS nanoscience Au · 2023Article
- Discriminating Glioblastoma from Peritumoral Tissue by a Nanohole Array-Based Optical and Label-Free Biosensor.Biosensors · 2023Article
161 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
Parasitization by malaria-inducing Plasmodium falciparum leads to structural, biochemical, and mechanical modifications to the host red blood cells (RBCs). To study these modifications, we investigate two intrinsic indicators: the refractive index and membrane fluctuations in P. falciparum-invaded human RBCs (Pf-RBCs). We report experimental connections between these intrinsic indicators and pathological states. By employing two noninvasive optical techniques, tomographic phase microscopy and diffraction phase microscopy, we extract three-dimensional maps of refractive index and nanoscale cell membrane fluctuations in isolated RBCs. Our systematic experiments cover all intraerythrocytic stages of parasite development under physiological and febrile temperatures. These findings offer potential, and sufficiently general, avenues for identifying, through cell membrane dynamics, pathological states that cause or accompany human diseases.
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