ArticleLearning & memory (Cold Spring Harbor, N.Y.)2008
Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The role of non-coding RNAs in the formation of long-term associative memory after single-trial learning inFrontiers in behavioral neuroscience · 2022Review
- The unlimited potential of the great pond snail,eLife · 2020Article
- Long-Term DL-3-Frontiers in aging neuroscience · 2018Article
- Phosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity.Brain structure & function · 2016Article
- pT305-CaMKII stabilizes a learning-induced increase in AMPA receptors for ongoing memory consolidation after classical conditioning.Nature communications · 2014Article
- Susceptibility of memory consolidation during lapses in recall.Nature communications · 2013Article
- Spatial memory deficits and motor coordination facilitation in cGMP-dependent protein kinase type II-deficient mice.Neurobiology of learning and memory · 2013Article
- Critical role for protein kinase A in the acquisition of gregarious behavior in the desert locust.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors are present and biochemically active in the central nervous system of the pond snail Lymnaea stagnalis.Journal of molecular neuroscience : MN · 2010Article
- A homolog of the vertebrate pituitary adenylate cyclase-activating polypeptide is both necessary and instructive for the rapid formation of associative memory in an invertebrate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Delayed intrinsic activation of an NMDA-independent CaM-kinase II in a critical time window is necessary for late consolidation of an associative memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Transcriptomic profiling of central nervous system regions in three species of honey bee during dance communication behavior.PloS one · 2009Article
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Authors and funding
4 authors.
Funding
Abstract
The cAMP-dependent protein kinase (PKA) is known to play a critical role in both transcription-independent short-term or intermediate-term memory and transcription-dependent long-term memory (LTM). Although distinct phases of LTM already have been demonstrated in some systems, it is not known whether these phases require distinct temporal patterns of learning-induced PKA activation. This question was addressed in a robust form of associative LTM that emerges within a matter of hours after single-trial food-reward classical conditioning in the pond snail Lymnaea stagnalis. After establishing the molecular and functional identity of the PKA catalytic subunit in the Lymnaea nervous system, we used a combination of PKA activity measurement and inhibition techniques to investigate its role in LTM in intact animals. PKA activity in ganglia involved in single-trial learning showed a short latency but prolonged increase after classical conditioning. However, while increased PKA activity immediately after training (0-10 min) was essential for an early phase of LTM (6 h), the late phase of LTM (24 h) required a prolonged increase in PKA activity. These observations indicate mechanistically different roles for PKA in recent and more remote phases of LTM, which may underpin different cellular and molecular mechanisms required for these phases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.