ArticleLearning & memory (Cold Spring Harbor, N.Y.)2008
Neonatal odor-shock conditioning alters the neural network involved in odor fear learning at adulthood.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Olfactory bulb activity shapes the development of entorhinal-hippocampal coupling and associated cognitive abilities.Current biology : CB · 2023Article
- Neural processing of the reward value of pleasant odorants.Current biology : CB · 2021Article
- Early-life adversity and neurological disease: age-old questions and novel answers.Nature reviews. Neurology · 2019Review
- Unique infant neurobiology produces distinctive trauma processing.Developmental cognitive neuroscience · 2019Review
- Development of Threat Expression Following Infant Maltreatment: Infant and Adult Enhancement but Adolescent Attenuation.Frontiers in behavioral neuroscience · 2019Article
- Learning-Dependent and -Independent Enhancement of Mitral/Tufted Cell Glomerular Odor Responses Following Olfactory Fear Conditioning in Awake Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Differential effects of predictable vs. unpredictable aversive experience early in development on fear memory and learning in adulthood.Behavioral neuroscience · 2018Article
- The neurobiology of safety and threat learning in infancy.Neurobiology of learning and memory · 2017Review
- Early life adversity during the infant sensitive period for attachment: Programming of behavioral neurobiology of threat processing and social behavior.Developmental cognitive neuroscience · 2017Review
- Neurobehavioral assessment of maternal odor in developing rat pups: implications for social buffering.Social neuroscience · 2017Article
- Unique neurobiology during the sensitive period for attachment produces distinctive infant trauma processing.European journal of psychotraumatology · 2016Review
- Parental buffering of fear and stress neurobiology: Reviewing parallels across rodent, monkey, and human models.Social neuroscience · 2015Review
- Optogenetic Stimulation of Lateral Amygdala Input to Posterior Piriform Cortex Modulates Single-Unit and Ensemble Odor Processing.Frontiers in neural circuits · 2015Article
- Differential involvement of amygdala and cortical NMDA receptors activation upon encoding in odor fear memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Infantile amnesia: forgotten but not gone.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Review
- Unpredictable neonatal stress enhances adult anxiety and alters amygdala gene expression related to serotonin and GABA.Neuroscience · 2014Article
- Infant rats can learn time intervals before the maturation of the striatum: evidence from odor fear conditioning.Frontiers in behavioral neuroscience · 2014Article
- Early life trauma and attachment: immediate and enduring effects on neurobehavioral and stress axis development.Frontiers in endocrinology · 2014Review
- The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome.Psychoneuroendocrinology · 2013Review
- It's time to fear! Interval timing in odor fear conditioning in rats.Frontiers in behavioral neuroscience · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Adult learning and memory functions are strongly dependent on neonatal experiences. We recently showed that neonatal odor-shock learning attenuates later life odor fear conditioning and amygdala activity. In the present work we investigated whether changes observed in adults can also be observed in other structures normally involved, namely olfactory cortical areas. For this, pups were trained daily from postnatal (PN) 8 to 12 in an odor-shock paradigm, and retrained at adulthood in the same task. (14)C 2-DG autoradiographic brain mapping was used to measure training-related activation in amygdala cortical nucleus (CoA), anterior (aPCx), and posterior (pPCx) piriform cortex. In addition, field potentials induced in the three sites in response to paired-pulse stimulation of the olfactory bulb were recorded in order to assess short-term inhibition and facilitation in these structures. Attenuated adult fear learning was accompanied by a deficit in 2-DG activation in CoA and pPCx. Moreover, electrophysiological recordings revealed that, in these sites, the level of inhibition was lower than in control animals. These data indicate that early life odor-shock learning produces changes throughout structures of the adult learning circuit that are independent, at least in part, from those involved in infant learning. Moreover, these enduring effects were influenced by the contingency of the infant experience since paired odor-shock produced greater disruption of adult learning and its supporting neural pathway than unpaired presentations. These results suggest that some enduring effects of early life experience are potentiated by contingency and extend beyond brain areas involved in infant learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.