ArticleRNA (New York, N.Y.)2008
Screening of human SNP database identifies recoding sites of A-to-I RNA editing.
Article in RNA (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Article
- Novel Regulators of the IGF System in Cancer.Biomolecules · 2021Review
- Diagnostic Value of Serum Insulin-Like Growth Factor Binding Protein 7 (IGFBP7) in Colorectal Cancer.OncoTargets and therapy · 2020Article
- ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications.Annals of translational medicine · 2019Review
- ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma.International journal of oncology · 2017Article
- Identification of human RNA editing sites: A historical perspective.Methods (San Diego, Calif.) · 2016Review
- A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes.Genome research · 2014Article
- Mammalian conserved ADAR targets comprise only a small fragment of the human editosome.Genome biology · 2014Article
- RADAR: a rigorously annotated database of A-to-I RNA editing.Nucleic acids research · 2014Article
- Darned in 2013: inclusion of model organisms and linking with Wikipedia.Nucleic acids research · 2013Article
- A strategy for developing a hammerhead ribozyme for selective RNA cleavage depending on substitutional RNA editing.RNA (New York, N.Y.) · 2012Article
- Spatio-temporal regulation of ADAR editing during development in porcine neural tissues.RNA biology · 2012Article
- Extra double-stranded RNA binding domain (dsRBD) in a squid RNA editing enzyme confers resistance to high salt environment.The Journal of biological chemistry · 2012Article
- Accurate identification of A-to-I RNA editing in human by transcriptome sequencing.Genome research · 2012Article
- Identification of widespread ultra-edited human RNAs.PLoS genetics · 2011Article
- Disease-associated mutations that alter the RNA structural ensemble.PLoS genetics · 2010Article
- A mammalian reporter system for fast and quantitative detection of intracellular A-to-I RNA editing levels.Analytical biochemistry · 2010Article
- A computational screen for site selective A-to-I editing detects novel sites in neuron specific Hu proteins.BMC bioinformatics · 2010Article
- Functions and regulation of RNA editing by ADAR deaminases.Annual review of biochemistry · 2010Review
- Evidence for large diversity in the human transcriptome created by Alu RNA editing.Nucleic acids research · 2009Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single nucleotide polymorphisms (SNPs) are DNA sequence variations that can affect the expression or function of genes. As a result, they may lead to phenotypic differences between individuals, such as susceptibility to disease, response to medications, and disease progression. Millions of SNPs have been mapped within the human genome providing a rich resource for genetic variation studies. Adenosine-to-inosine RNA editing also leads to the production of RNA and protein sequence variants, but it acts on the level of primary gene transcripts. Sequence variations due to RNA editing may be misannotated as SNPs when relying solely on expressed sequence data instead of genomic material. In this study, we screened the human SNP database for potential cases of A-to-I RNA editing that cause amino acid changes in the encoded protein. Our search strategy applies five molecular features to score candidate sites. It identifies all previously known cases of editing present in the SNP database and successfully uncovers novel, bona fide targets of adenosine deamination editing. Our approach sets the stage for effective and comprehensive genome-wide screens for A-to-I editing targets.
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