ArticleThe Journal of physiology2008
Spontaneous glutamatergic activity induces a BDNF-dependent potentiation of GABAergic synapses in the newborn rat hippocampus.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed.
- Time-dependent homeostatic mechanisms underlie brain-derived neurotrophic factor action on neural circuitry.Communications biology · 2023Article
- Brain-Derived Neurotrophic Factor Is Involved in Activity-Dependent Tonotopic Refinement of MNTB Neurons.Frontiers in neural circuits · 2022Article
- Nitric Oxide Signaling Pathway in Ventral Tegmental Area is Involved in Regulation of 7,8-Dihydroxyflavone on Alcohol Consumption in Rats.Molecular neurobiology · 2022Article
- Enhanced Non-Associative Long-Term Potentiation in Immature Granule Cells in the Dentate Gyrus of Adult Rats.Frontiers in synaptic neuroscience · 2022Article
- Emergence of local and global synaptic organization on cortical dendrites.Nature communications · 2021Article
- Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus.Frontiers in cellular neuroscience · 2020Article
- 7,8-Dihydroxyflavone Attenuates Alcohol-Related Behavior in Rat Models of Alcohol Consumption via TrkB in the Ventral Tegmental Area.Frontiers in neuroscience · 2020Article
- Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity.Nature reviews. Neuroscience · 2019Review
- Neurotransmitter-mediated activity spatially controls neuronal migration in the zebrafish cerebellum.PLoS biology · 2018Article
- Article
- Pro-brain-derived neurotrophic factor inhibits GABAergic neurotransmission by activating endocytosis and repression of GABAA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Low-intensity repetitive transcranial magnetic stimulation improves abnormal visual cortical circuit topography and upregulates BDNF in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Leptin potentiates GABAergic synaptic transmission in the developing rodent hippocampus.Frontiers in cellular neuroscience · 2014Article
- Characterization of L-type voltage-gated Ca(2+) channel expression and function in developing CA3 pyramidal neurons.Neuroscience · 2013Article
- NMDA-dependent switch of proBDNF actions on developing GABAergic synapses.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- Neurotrophin regulation of neural circuit development and function.Nature reviews. Neuroscience · 2013Review
- Long-term plasticity at inhibitory synapses.Current opinion in neurobiology · 2011Review
- The many forms and functions of long term plasticity at GABAergic synapses.Neural plasticity · 2011Review
- Low concentrations of alcohol inhibit BDNF-dependent GABAergic plasticity via L-type Ca2+ channel inhibition in developing CA3 hippocampal pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Normal hearing is required for the emergence of long-lasting inhibitory potentiation in cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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No grant is acknowledged in the PubMed record.
Abstract
Spontaneous ongoing synaptic activity is thought to play an instructive role in the maturation of the neuronal circuits. However the type of synaptic activity involved and how this activity is translated into structural and functional changes is not fully understood. Here we show that ongoing glutamatergic synaptic activity triggers a long-lasting potentiation of gamma-aminobutyric acid (GABA) mediated synaptic activity (LLP(GABA-A)) in the developing rat hippocampus. LLP(GABA-A) induction requires (i) the activation of AMPA receptors and L-type voltage-dependent calcium channels, (ii) the release of endogenous brain-derived neurotrophic factor (BDNF), and (iii) the activation of postsynaptic tropomyosin-related kinase receptors B (TrkB). We found that spontaneous glutamatergic activity is required to maintain a high level of native BDNF in the newborn rat hippocampus and that application of exogenous BDNF induced LLP(GABA-A) in the absence of glutamatergic activity. These results suggest that ongoing glutamatergic synaptic activity plays a pivotal role in the functional maturation of hippocampal GABAergic synapses by means of a cascade involving BDNF release and downstream signalling through postsynaptic TrkB receptor activation.
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