ArticleThe Journal of physiology2008
Acting locally but sensing globally: impact of GABAergic synaptic plasticity on phasic and tonic inhibition in the thalamus.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Tonic GABAergic inhibition, via GABAThe European journal of neuroscience · 2021Article
- Basal ganglia-thalamus and the "crowning enigma".Frontiers in neural circuits · 2015Review
- Is GABA neurotransmission enhanced in auditory thalamus relative to inferior colliculus?Journal of neurophysiology · 2014Article
- Protein kinase C regulates tonic GABA(A) receptor-mediated inhibition in the hippocampus and thalamus.The European journal of neuroscience · 2013Article
- The role of nitric oxide in pre-synaptic plasticity and homeostasis.Frontiers in cellular neuroscience · 2013Review
- Metabotropic regulation of extrasynaptic GABAA receptors.Frontiers in neural circuits · 2013Review
- Non-Hebbian long-term potentiation of inhibitory synapses in the thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Copper block of extrasynaptic GABAA receptors in the mature cerebellum and striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Tonic inhibition sets the state of excitability in olfactory bulb granule cells.The Journal of physiology · 2013Article
- GABAA , NMDA and mGlu2 receptors tonically regulate inhibition and excitation in the thalamic reticular nucleus.The European journal of neuroscience · 2013Article
- Presynaptic LTP and LTD of excitatory and inhibitory synapses.Cold Spring Harbor perspectives in biology · 2012Review
- mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Long-term plasticity at inhibitory synapses.Current opinion in neurobiology · 2011Review
- Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Presynaptic plasticity: targeted control of inhibitory networks.Current opinion in neurobiology · 2009Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have discovered that adult thalamocortical relay neurones exhibit a sustained enhancement of synaptic inhibition triggered by transient action potential firing of a single thalamic relay neurone. The sustained activity-dependent increase in IPSC frequency (+48.3 +/- 11.4%, n = 32) was blocked by chelating calcium inside an individual cell, by scavenging nitric oxide or by blocking NMDA receptor activation in the thalamus. Surprisingly, the tonic inhibition that is known to result from extrasynaptic GABA(A) receptor activation in these cells was unaffected by this local form of plasticity. However, tonic inhibition was increased (+131.9 +/- 56.5%, n = 13) following widespread changes in GABA release across the thalamus. These data suggest that thalamocortical sleep-state oscillations requiring membrane hyperpolarization will be influenced by global sensing of GABA release acting through extrasynaptic GABA(A) receptors. In contrast, local changes in GABA release of the type observed following this novel form of activity-dependent plasticity will influence local integration of sensory information without changing levels of tonic inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.