Evidence map›Paper›PMID 18771457›Full record

ArticleJournal of the American Geriatrics Society2008

Discontinuing medications: a novel approach for revising the prescribing stage of the medication-use process.

Kevin T Bain, Holly M Holmes, Mark H Beers, Vittorio Maio, Steven M Handler, Stephen G Pauker

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Geriatrics Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04288193 (Implementation of a Pharmacist-Driven Antipsychotic Deprescribing Initiative in the Program of All-inclusive Care for the Elderly), which is not on this map. Cited by 91 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04288193 withdrawnnot on this mapstarted 2021, after this paper: background citation

Implementation of a Pharmacist-Driven Antipsychotic Deprescribing Initiative in the Program of All-inclusive Care for the Elderly (PACE) Setting: A Pilot Study

Typeobservational_patient_registrySponsorTabula Rasa HealthCareRan2021 to 2022Enrolled0ConditionsBehavioral and Psychiatric Symptoms of Dementia, InsomniaArmsRecommendation to Deprescribe
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  20. The Health Costs of Cost Sharing.The quarterly journal of economics · 2024
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kevin T BainDepartment of Quality Outcomes, excelleRx Inc, an Omnicare Company, Philadelphia, Pennsylvania 19102, USA. kbain@excellerx.com
Holly M Holmes
Mark H Beers
Vittorio Maio
Steven M Handler
Stephen G Pauker

Funding

University of Pittsburgh Clinical and Translational Science InstitutionKL2RR024154 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$22.2M
University of Pittsburgh Clinical and Translational Science InstitutionKL2TR000146 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$8.7M
NCATS NIH HHS KL2 TR000146NCRR NIH HHS 1 KL2 RR024154-01NCRR NIH HHS KL2 RR024154NIA NIH HHS L30 AG026830
6 · The paper itself

Abstract

Thousands of Americans are injured or die each year from adverse drug reactions, many of which are preventable. The burden of harm conveyed by the use of medications is a significant public health problem, and therefore, improving the medication-use process is a priority. Recent and ongoing efforts to improve the medication-use process have focused primarily on improving medication prescribing, and not much emphasis has been put on improving medication discontinuation. A formalized approach for rationally discontinuing medications is a necessary antecedent to improving medication safety and improving the nation's quality of care. This article proposes a conceptual framework for revising the prescribing stage of the medication-use process to include discontinuing medications. This framework has substantial practice and research implications, especially for the clinical care of older persons, who are particularly susceptible to the adverse effects of medications.

Indexed as

PolypharmacyAgedAged, 80 and overDrug InteractionsDrug PrescriptionsDrug-Related Side Effects and Adverse ReactionsDrug TherapyDrug UtilizationHumansSubstance Withdrawal Syndrome

Identifiers

PMID18771457
PMCPMC3119470

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.