ArticleMetabolic brain disease2008
Age-related changes of calcineurin and Akt1/protein kinase Balpha (Akt1/PKBalpha) immunoreactivity in the mouse hippocampal CA1 sector: an immunohistochemical study.
Article in Metabolic brain disease, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging.Frontiers in cell and developmental biology · 2022Article
- Article
- Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Role of inducible or neuronal nitric oxide synthase in neurogenesis of the dentate gyrus in aged mice.Metabolic brain disease · 2010Article
- Decrease in PTEN and increase in Akt expression and neuron size in aged rat spinal cord.Experimental gerontology · 2010Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
We investigated the age-related alterations of calcineurin and Akt1/protein kinase Balpha (Akt1/PKBalpha) immunoreactivity in the mouse hippocampal CA1 sector using immunohistochemistry. Calcineurin and Akt1/PKBalpha immunoreactivity was measured in 2-, 8-, 18-, 40-42- and 50-59-weeks-old animals. Diffuse calcineurin immunoreactivity was evident in pyramidal neurons of the hippocampal CA1 sector of 8-weeks-old mice. Densities of calcineurin immunoreactivity were lowered significantly in the hippocampal CA1 neurons of 2-weeks-old mice. In contrast, densities of calcineurin immunoreactivity were unchanged in the hippocampal CA1 neurons up to 40-42-weeks-old mice. However, densities of calcineurin immunoreactivity were increased significantly in the dendrites and plasma membranes of the hippocampal CA1 neurons of 50-59-weeks-old mice compared to 8-weeks old animals. Akt1/PKBalpha immunoreactivity was slightly detectable in the hippocampal CA1 sector of 8-weeks-old mice. A weak Akt1/PKBalpha immunoreactivity was found in cytoplasm of the hippocampal CA1 neurons and glial cells. Densities of Akt1/PKBalpha immunoreactivity were unchanged in the hippocampal CA1 neurons and glial cells of 2-weeks-old mice. In contrast, densities of Akt1/PKBalpha immunoreactivity were increased significantly in cytoplasm of neurons and glial cells of the hippocampal CA1 sector from 40-42 to 50-59 weeks after birth. The present study indicates that densities of calcineurin immunoreactivity and number of Akt1/PKBalpha immunoreactive cells were increased significantly in the hippocampal CA1 sector during aging processes. Our study also demonstrates that the activation of Akt1/PKBalpha signaling pathway may act defense mechanism against the neuronal dysfunction of the hippocampal CA1 sector caused by the activation of calcineurin signaling pathway during aging processes. These findings suggest that the calcineurin and Akt1/PKBalpha signaling pathway may be important targets for the development of novel therapeutic strategies for protection against age-related neurodegeneration.
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