ArticleRheumatology international2009
No significant association between genetic polymorphisms in the TNAP gene and ankylosing spondylitis in the Chinese Han population.
Article in Rheumatology international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients.Drug design, development and therapy · 2016Article
- The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population.Rheumatology international · 2011Article
- Recent studies on the genetic basis of ankylosing spondylitis.Current rheumatology reports · 2009Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) in tissue non-specific alkaline phosphatase (TNAP) with ankylosing spondylitis (AS) in the Chinese Han population. We carried out both case-control studies in two independent Chinese AS cohorts (Eastern Chinese, Southeastern Chinese) involving 353 AS patients and 514 unrelated healthy controls and family-based association study involving 57 pedigrees. Two TNAP intronic SNPs rs3767155 (G/A), and rs1780329 (G/T) and 1 exonic variant rs3738099 (A/G) were genotyped using direct DNA sequencing method. The results showed that there was no significant difference in allele, genotype or haplotype frequencies between the AS patients and the controls at the three SNPs in either case-control or family-based association study, which indicated that the TNAP gene was unlikely to play a major role in the susceptibility to AS in the Chinese Han population.
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